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Study of anti-inflammatory activity of omeprazole in complete Freundís adjuvant induced arthritic rats

Nadia Nausheen, Prabhakar Patil, Yatish Byndoor.

Abstract
Background: Rheumatoid arthritis (RA) is a chronic, progressive, and systemic inflammatory disease, characterized by synovial proliferation and joint erosions. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used as an important part of therapeutic regime to suppress the pain and inflammation associated with RA. The modern drugs both steroidal and nonsteroidal anti-inflammatory drugs (NSAIDS) and disease modifying antirheumatic drugs (DMARDSs) are used for the amelioration of the symptoms of the disease; however, they offer only temporary relief and also produce adverse effects. This study was done to evaluate anti-inflammatory activity of Omeprazole in CFA induced arthritic rats.
Methods: Animals were divided into five groups of six each, group I as control, group II as standard whereas groups III, IV and V as test groups (three doses). Anti-inflammatory effect of group II Diclofenac sodium (10 mg/kg orally) and group III, IV and V received Omeprazole (10mg/kg, 20mg/kg, and 30mg/kg bodyweight orally respectively) was evaluated in adult albino rats by Plethysmometer on 7th, 14th and 21st day post adjuvant injection.
Results: Group 3 produced a significant suppression of paw volume with P value (

Key words: CFA, NSAIDS, PPI, RA


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