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Original Research

RMJ. 2017; 42(3): 302-305


Evaluation of platelet parameters (PDW and MPV) for differentiation between clonal thrombocytosis and reactive thrombocytosis

Tanzeel Imran, Lubna Zafar, Humera Naz Altaf, Saif Orakzai, Tariq Butt, Farid Bakhtiar.

Abstract
Objective: To establish the diagnostic effectiveness of platelets parameters i.e. platelets distribution width (PDW) and mean platelet volume (MPV) in differential diagnosis of thrombocytosis (clonal thrombocytosis /reactive thrombocytosis).
Methodology: This cross-sectional study was carried out at Hematology department at Fauji Foundation Hospital, Rawalpindi, Pakistan from Feb 2012 to March 2013. A total of 148 patients were studied. Out of these, equal number had myeloproliferative disorders (MPD) and reactive thrombocytosis (RT). The complete blood picture was done on auto-analyzer Sysmex XT (2000i) and platelet count, PDW and MPV were determined.
Results: Out of 148 patients with thrombocytosis, the range of PDW was 10-20 % for clonal thrombocytosis (CT) with a mean value of 14.32.2% and for RT the range of PDW was 7-13% and the mean value was 91.3%. The mean MPV for CT was 11.71.6fl and for RT was 8.500.6fl with a range of 8.7-18.5fl for CT and 7.2-10.4fl for RT. The t test was applied on the mean of MPV and PDW of clonal and reactive thrombocytosis (p

Key words: Clonal thrombocytosis, Reactive thrombocytosis, platelets distribution width PDW, Mean platelet volume MPV.



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