Home    eJManager.com Add Your Journal   |    Follow on Twitter   |    Subscribe to List

Directory for Medical Articles
 

Open Access

Original Research



Evaluation of pharmacological and toxicological studies of an ayurvedic medicine Rasaraj Ras on biological system of the male Sprague-Dawley rats

Ferdousi Akter, Md. Mamun Sikder, Shemonty Hasan, Israt Jabin Emu, Massnoon Ali, Manoth Kumer Biswas, Nilay Saha, M. S. K. Choudhuri.

Abstract
Background: In this study, the pharmacological and toxicological effects along with possible side effects of the classical ayurvedic formulation Rasaraj Ras (RR) which is used as a traditional medicine in the treatment of hemiplegia in the rural population were evaluated.
Methods: During this study, various experiments on body growth rate, organ-body weight ratio and tissue hydration indices were performed to evaluate its efficacy and toxicity. To find out the toxicological characteristic of RR, it was administered chronically to the male Sprague-Dawley rats at a dose of 40 mg/kg. After 28 days chronic administration of the RR preparation the following toxicological changes were noted.
Results: All throughout the experimental period the RR treated animals were always maintaining negligible changes in body weight, but all throughout the experimental period no statistically significant increase or decrease was noted. There is a statistically significant decrease in the relative percent weight of the male rat heart. There is a statistically highly significant decrease in the absolute weight of the male rat liver. There is a statistically highly significant decrease in the relative percent weight of the male rat liver. There is a statistically significant decrease in the relative percent weight of the male rat kidney. In the tissue hydration index determination, no significant changes were noted in case of any organ.
Conclusions: As RR decreases abnormally weight of several organs in body of treated rats, so it should not be administered chronically at a higher dose.

Key words: Absolute weight, Organ percent weight, Organ water content Pharmacological, Rasaraj Ras, Toxicological


Full text links

Share this Article




ScopeMed Home
Follow ScopeMed on Twitter
Article Tools
Job Opportunities/Service Offers
eJManager OJMS
eJPort Journal Hosting
About ScopeMed
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Service of eJManager LLC Publishing for Scientific Publications. Copyright © ScopeMedź Information Services.
Scopemed Buttons