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Prevalence of aspirin resistance in coronary artery disease among Indian patients

Sibi Narayanan Syamalakumari, Abhilash Kannan, Geethu Gopinathan Nair.

Abstract
Background: Aspirin is one of the most widely consumed drugs in this world. The first report of a possible antithrombotic effect of aspirin appeared in 1953 in the Mississippi Valley Medical Journal. Objective of the study was to determine the prevalence of aspirin resistance among Indian patients with coronary artery disease.
Methods: Patients were prospectively enrolled from all stable cardiac patients presenting to the outpatient wing of Department of Medicine of a tertiary care centre in South Kerala. Duration of study was one year. All patients who were more than 21years old and who had taken 150mg of aspirin for the previous seven days were eligible for enrolment.
Results: Aspirin resistance was found in 9.3% of patients. 17.3% of patients were aspirin semi responder.
Conclusions: There was statistically significant correlation of aspirin resistance with presence of diabetes mellitus, systemic hypertension and dyslipidemia. Cigarette smoking did not show any significant association with aspirin resistance.

Key words: Aspirin, Aspirin resistance, Coronary artery disease, Dyslipidemia, Platelet aggregation, Platelet rich plasma


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