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Effect of Trigonella foenum (methi) on fasting blood glucose levels in alloxan induced diabetes in rabbits

Ghulam Subhani, Ayesha Vaseem.

Background: Water-retaining fibers, especially the mucilaginous compounds, such as the gel fiber present in Fenugreek seeds, reduce the rate of glucose absorption and may also delay gastric emptying thereby preventing the rise in blood sugar levels following a meal. In addition to its hypoglycemic effects, the hyperlipidemic effect of Fenugreek fibers has also been documented. The objective of the study was to study the effect of Trigonella foenum (methi) on Fasting Blood Glucose levels in Alloxan induced diabetes in Rabbits.
Methods: Fenugreek seed extract was prepared. Study was carried out on alloxan induced diabetic rabbits. They were prepared for the study. Then they were grouped into 5 groups depending upon the drugs used for them. The drug solutions were prepared and administered to diabetic rabbits. The blood sugar levels were recorded before and after treatment for first 15 days and once in week for next three weeks. Daily fasting blood sugar readings were taken. The blood glucose was determined with standard procedures and methods.
Results: Alcohol extract of fenugreek seeds using soxhlet apparatus produced significant (P

Key words: Alloxan, Rabbits, Trigonella foenum

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