Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access

Original Research

Characteristics, determinants and cost implications of severe adverse drug reactions in the intensive coronary care unit of a hospital

Nitin S. Kunnoor, Anand R. Kanaki, Sharanabasappa Singanal.

Background: The objective of the study was to determine the predictors, frequency, characteristics and incremental costs of severe Adverse Drug Reactions in the Intensive Coronary Care Unit (ICCU) of a hospital.
Methods: Two trained physicians prospectively reviewed case records of all in-patients admitted to ICCU over one year (July 2015 to June 2016) and identified ADRs. Each ADR was assessed for causality, severity, predictability and preventability. Determinants of severe ADRs were identified using multiple binary logistic regression analysis. Cost of severe ADR was estimated based on the corrected duration of excess hospital stay after adjusting for age, gender, co-morbid conditions and number of drugs.
Results: Of 573 cases admitted during one year, 47 (8%) patients had 56 severe ADRs. Streptokinase (16.1%) was the commonest drug associated with severe ADRs. Arrhythmias (30.4%) were the commonest severe ADR. Presence of arrhythmias (OR 4.54, 95% CI 2.259.14), renal dysfunction (OR 2.27, 95% CI 1.015.11) and poly-pharmacy (>10 drugs) (OR 1.13, 95% CI 1.007- 1.254) were found to be the predictors for occurrence of severe ADRs. Majority of severe ADRs were found to be probable 30 (53.6%). 46 (82%) were predictable and 25 (44.6%) probably preventable severe ADRs. Patients with severe ADRs had a longer duration of ICCU (0.8 extra day) and hospital stay (1.5 extra days) (adjusted analysis). The mean incremental cost incurred by patients in the severe ADR group was $ 32 (INR 2170/-) per patient based on the corrected duration of hospital stay.
Conclusions: Severe ADRs in ICCU add considerably to treatment costs. Cardiac arrhythmias, renal dysfunction, and polypharmacy are important predictors of severe ADRs.

Key words: ADRs, Cost, ICCU

Share this Article

Oxidants and Antioxidants in Medical Science


ScopeMed Home
Follow ScopeMed on Twitter
Article Tools
eJPort Journal Hosting
About ScopeMed
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons