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Wound healing activity of topical phenytoin in excision wound model of Albino rats

Usha N. S., Sirisha G..

Background: Wound healing is a major medical entity. Phenytoin being an anticonvulsant drug has shown promising results in healing chronic wounds. In the present study we have evaluated the effect of topical Phenytoin on excision wound models of albino rats.
Methods: Phenytoin ointment of 1%, 5% and 10% were used topically on experimental animals. Neomycin used as reference standard. In Excision wound model period of epithelialization, area of wound and hydroxyproline content were evaluated.
Results: Phenytoin 1%, 5% and 10% have shown significant (P

Key words: Excision wound, Hydroxyproline, Phenytoin, Wound healing

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Archives of Clinical and Experimental Surgery (ACES)


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