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A 3 year retrospective study on gestational trophoblastic disease in a government obstetrical tertiary care centre

Veeraraghavan Gurusamy, Madurai Padmanabhan Kanchana, Lakshmi Narasimhan Srinivasan.

Background: The aim of this study is to assess the post diagnostic outcome of Gestational Trophoblastic Disease, a heterogeneous group of disorders, in a government obstetrical tertiary care centre.
Methods: The study was conducted in the Institute of Obstetrics & Gynecology, Madras Medical College as a retrospective study. A total of 75 cases were studied over a 3 year period from January 2012 to December 2015. The parameters which were studied included age group, antecedent pregnancy, beta hCG values, histopathological types and Treatment profile.
Results: Of the 75 cases, 55 cases (73%) were in the 21-39 age group. The spectrum of disorders that were studied included 69 cases of complete mole, 2 cases of partial mole, 1 case of twin pregnancy with single live foetus and partial mole, 1 case of triplet pregnancy with two live foetuses and partial mole, 1 case of epithelioid trophoblastic tumour and 1 case of choriocarcinoma. Of the 75 cases, 16 cases underwent chemotherapy. No mortality was observed during the study period.
Conclusions: Close monitoring and follow up with beta hCG values is of utmost importance in the management of Gestational trophoblastic disease. In cases of gestational trophoblastic neoplasia (GTN), WHO/FIGO scoring should be done and managed with chemotherapy according to the risk assessment.

Key words: Beta hCG, Choriocarcinoma, Chemotherapy, Epithelioid trophoblastic tumour, Gestational trophoblastic disease, Gestational trophoblastic neoplasia

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American Journal of Physiology, Biochemistry and Pharmacology


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