Home    eJManager.com Add Your Journal   |    Follow on Twitter   |    Subscribe to List

Directory for Medical Articles
 

Open Access

Original Research



Endothelial nitric oxide synthase gene glu298asp polymorphism in preterm neonates with respiratory distress syndrome

Mona Abdel-Wahab Albeshery, Omima Mohamed Abdel-Haie, Nesrein Salama Ramadan, Shuzan Ali Mohammed.

Abstract
Background: Neonatal respiratory distress syndrome (RDS) is a multifactorial disease of preterm influenced by many factors including gene polymorphism. The aim of the present study was to determine the effect of endothelial nitric oxide synthase gene glu298asp polymorphism (rs1799983) in developing and grading of RDS in preterm neonates.
Methods: This study was performed on 65 preterm neonates; 40 with RDS and 25 healthy controls. Genotyping of endothelial nitric oxide synthase gene glu298asp polymorphism was performed by restriction fragment length polymorphism.
Results: There were statistical significant increases in TT, (GT+TT) genotypes and T allele frequencies of rs1799983 among RDS neonates compared to controls. As groups were categorized by gestational age; TT genotype and T allele frequencies were statistically significantly increased in 33-35weeks RDS neonates compared to controls. TT genotype in RDS was associated with RDS grade III, mechanical ventilation need, and increased mortality. TT genotype, T allele, gestational age (

Key words: Endothelial nitric oxide synthase, Polymorphism, RDS, RFLP, rs1799983


Full text links

Share this Article




ScopeMed Home
Follow ScopeMed on Twitter
Article Tools
Job Opportunities/Service Offers
eJManager OJMS
eJPort Journal Hosting
About ScopeMed
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Service of eJManager LLC Publishing for Scientific Publications. Copyright © ScopeMedź Information Services.
Scopemed Buttons