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A pilot study on effectiveness of oral mucositis pain control in hematopoietic stem cell transplant patients

Shu Ping Wong, Farida Islahudin.

Abstract
Effectiveness of oral mucositis (OM) pain control with the current standard of care management were assessed using clinician and self-reported scales in haematopoietic stem cell transplant (HSCT) patients. A prospective observational study was performed using clinician-assessed (World Health Organization-WHO) Oral Toxicity Scales and self-reported scales (Oral Mucositis Daily Questionnaires-OMDQ). A total of 23 HSCT patients were included in the study. There were 100-recorded-days of OM using WHO scores, and 144-recorded-days of OM using OMDQ. A total of 14/23 (60.9%) patients experienced mucositis. The presence of OM was significantly associated with increase in actual body weight (t(21)=2.15, p=0.044), body surface area (t(21)=2.31, p=0.031) and body mass index (t(21)=2.13, p=0.044), longer hospital stays (t(21)=2.45, p=0.023) and busulphan-based regimens (=4.32, p=0.038). The degree of pain relief was significantly inversely correlated to both the degree of WHO graded OM severity (ρ=-0.586; p

Key words: Mucositis, stem cell transplant, WHO oral toxicity scale, OMDQ, pain



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