Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Article

J Liaquat Uni Med Health Sci. 2008; 7(2): 79-82


Prevalence of Drug Resistance in Pulmonary Tuberculosis

Muzaffar A. Shaikh, Nisar Ahmed Khokar, Narinder Maheshwari and Iftikhar Qazi.

Abstract
OBJECTIVE: To determine the prevalence of primary and secondary drug resistance to first line
anti-tuberculous drugs.
STUDY DESIGN: A hospital-based cross-sectional observational study.
PLACE AND DURATION: Department of Medicine Liaquat University Hospital Hyderabad/ Jamshoro
& Institute of Chest Diseases Kotri from April 2005 to March 2007.
PATIENTS AND METHODS: Fifty cases of Pulmonary tuberculosis (TB) randomly selected from
both institutes who fulfilled the following criteria 1) Sputa showed positive smear for Acid Fast
bacilli on Zeil Nelson Stain.2) Chest x-ray showed shadow consistent with TB. A detailed history,
contact with TB patients, previous use of anti-tuberculous drugs and Chest x-ray was
done. Sputa of all patients were sent for detail report and culture sensitivity. Descriptive and
inferential statistical analysis was performed using SPSS version 14.0.
RESULTS: Among 50 patients, 28(56%) were males and 22(44%) females, age ranged from 16-80
years (38.14 + 15.69). All 50 (100%) patients presented with fever and cough, haemoptysis in 36
(72%), chest pain in 9(18%) and dyspnea in 11(22%) cases, anemia in 39(78%) and lymphadenopathy
in 12(24%). On chest x-ray examination, 19(38%) patients had multiple infiltrations,
cavitations in 10(20%), fibrosis in 9(18%), consolidation in 5(10%), pneumothorax in 4(8%) and
pleural effusion in 3(6%) cases. Sputum for AFB was positive in all cases. Twenty-one (42%)
culture positive patients were of primary resistance and 29(58%) were of secondary resistance.
Twenty (40%) were sensitive to five drugs, 9(18%) resistant to one drug, 11(22%) to two drugs, 7
(14%) to three drugs, 3(6%) to four drugs and none resistant to five drugs.
CONCLUSION: In our setting, the prevalence of resistance to anti-tuberculous drugs is high and
alarming. Strategy should be made for proper treatment and compliance of patients to avoid the
development of drug resistance.

Key words: Pulmonary tuberculosis, drug resistance, anti-tuberculous drugs.



Share this Article


Advertisement
American Journal of Preventive Medicine and Public Health

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
ScopeMed Home
Follow ScopeMed on Twitter
BiblioCAM
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons