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Original Article

J Liaquat Uni Med Health Sci. 2007; 6(3): 116-119


LACTIC ACID AND PH LEVELS AS THE AUTHENTIC AND RELIABLE DIAGNOSTIC TOOLS FOR THE ASSESSMENT OF THE FETAL ACIDEMIA

Nusrat Zareen, Muhammad Saleem Khanzada, Rukhsana Rubeen, Zakir Jalal Khanzada, Syed Touseef Ahmed, Shaheen Sharaf Shah and Syed Saud Hasan.

Abstract
OBJECTIVE: To identify the importance of acidemia in distressed neonates with its diagnosis
on confirmative basis and to evaluate its severity by the estimation of lactic acid (LA), pH, bicarbonate
(HCO-
3) ions and hemoglobin (Hb) in comparison to subjective criteria like Apgar score
(0 10), fetal heart rate 120-160 beats per minute and meconium staining of liquor which provides
vague diagnosis.
METHODS: This study was conducted at Basic Medical Sciences Institute, located at Jinnah
Postgraduate Medical Centre Karachi, Sindh Pakistan. It comprised of 40 full term neonates
with acidemia without any other co-morbidity and 40 matching controls.
RESULTS: In this study, fetal arterial blood acid base analysis showed that LA levels were significantly
high (P=0.001) and pH, HCO3
- and Hb levels were significantly low (P=0.001) in acidotic
neonates as compared to controls.
CONCLUSION: High LA levels with decreased pH, HCO3
- and Hb are associated with acidemia in
newborns, which reveal confirmative diagnosis with comparison to subjective criteria for diagnosis
of acidemia.

Key words: Fetal acidemia. Acid base balance. Lactic acid.



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