Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Article



Management of Decompensated Cirrhosis due to HbeAg-negative chronic HBV infection with Lamivudine monotherapy

Suhail Ahmed Almani, Abdul Sattar Memon, Jawed Memon, Allah Bachayo Memon, Iqbal Memon..

Abstract
OBJECTIVE: To evaluate the efficacy of long-term lamivudine monotherapy in patients with decompensated cirrhosis due to HbeAg-negative/HBV-DNA positive. DESIGN: Case - control study. SETTING: Departments of Medicine and Surgery, Liaquat University Hospital, Jamshoro, and Isra University Hospital Hyderabad, from March 2000 to June 2003. PATIENTS AND METHODS: We analyzed the clinical course and outcome of lamivudine treatment in 30 consecutive cirrhotics and compared with 30 HBV untreated HbeAg-negative controls. RESULTS: Significant clinical improvement, defined as a reduction of at least two points in Child-Pugh score was observed in 23 of the 30 treated patients (76.6%) versus none of the 30 patients in the control group (p< 0.0001) after a mean follow-up of 10.6 ± 2.1 (±SD) months. There were 10 deaths in the treated group versus 24 in the control group (p= 0.07). Patients with clinical improvement had better survival than patients with no improvement (p=0.04). CONCLUSION: Lamivudine monotherapy significantly improves liver function in HbeAg-negative decompensated cirrhosis.

Key words: Lamivudine. Liver Cirrhosis. Hepatitis B, Chronic. Hepatitis B e Antigens. Antiviral Agents. Reverse Transcriptase Inhibitors. Hepatitis B virus. Hepatitis B. Drug Resistance, Viral.



Share this Article


Advertisement
Archives of Clinical and Experimental Surgery (ACES)

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
ScopeMed Home
Follow ScopeMed on Twitter
BiblioCAM
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.
Scopemed Buttons