Background: Upper Gastrointestinal tract disorders are of the most frequently encountered cases in clinical practices. Endoscopic biopsy is common procedure to establish the diagnosis of different benign and malignant lesion. The biopsy specimen is used for histopathological study to confirm the endoscopic diagnosis in suspected malignancy and to rule out the benign appearing lesions for malignancy. The endoscopic biopsies are also used in monitoring the disease course, recurrence and response to therapy.
1. To study the overall frequency, age and sex distribution of various lesion.
2. To study varied spectrum of histopathological lesion both non-neoplastic and neoplastic in patients undergoing upper gastrointestinal biopsy.
Materials and Methods: The present study included endoscopic biopsies those were taken from patients, who were clinically diagnosed to have an upper gastrointestinal tract lesion needing biopsy, at the department of gastroenterology; Hi-Tech medical college. The selection of study material was prospective study (September 2012- August 2014).
Results: Out of the 72 upper GI endoscopic biopsy samples that were studied during the period of two years, 12 (16.66%) were from the oesophagus, 57 (79.17%) from stomach and 3 (4.17%) from duodenum. The highest incidence of upper GI endoscopic lesions was seen between 51-60 years of age. The male to female ratio in the present study was 2.6:1 which indicates male predominance.
Conclusion: There is predominance of malignancy compared to non neoplastic lesions in the present study. In patients below 50 years of age the most common lesion was gastritis and in patients more than 50 years of age the most common lesion was gastric malignancies. Endoscopic and histopathologic correlation was achieved in 84.72% of the cases. There is concordance of endoscopic biopsy findings with post biopsy resected specimens.
biopsy, endoscopy, upper GIT