P63 is basically a stem cell marker. It belongs to p53 protein family which comprises of transcription factors p53, p63, p73. P63 also possesses two isoforms which are interestingly with opposing characters. Its complexity remains unrevealed with helps in maintenance of genetic stability of germ cells, mechanisms of p63 behaves both monogenic as well as tumor suppressor of its various isoforms.
P53 family regulates many vital biological process including cell differentiation, proliferation and cell death / apoptosis. Phylogenetic analysis revealed that p53 family was originated from p63 / p73-like ancestral gene early in metazoan evolution.P63 shows expression in various neoplasms, it is typically used as stem cell marker. Various evidences show over expression of p63 in squamous cell carcinoma.
Unlike other exocrine glands salivary gland possess typical myoepithelial cells that have the ability to transform as neoplastic cell. Tumors of salivary glands are quiet interesting, based on studies done in population of atomic- bomb survivors in Hiroshima and Nagasaki, radiation seems to provoke salivary gland neoplasms.
In this review we are going to overlook anthropogenesis of p63 and its role in various neoplasms.
P63, Immunohistochemical Marker, Perplex neoplasm.