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Journal of Physiology and Pharmacology Advances
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ISSN: 2251-7693 (Online)
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Open Access

Original Research



Hepatoprotective Effects of Thymus and Salvia Essential oils on Paracetamol-Induced Toxicity in Rats

Hossny El Banna, Maher Soliman, Naser al wabel.

Cited by (1)

Abstract
Medicinal plants have been used traditionally worldwide for the prevention and treatment of liver disease. Thymus Capitatus and Salvia Officinal are used frequently as spices. The present investigation aimed to investigate the possible potential protective effect of Thymus and Salvia essential oils against Paracetamol induced hepatotoxicy. Administration of Paracetamol (500 mg/kg.b.wt) resulted in liver damage as manifested by significant increase in serum and hepatic lactate dehydrogenase (LDH) activity with a significant decrease in blood and hepatic glutathione (GSH) levels, as well as blood and hepatic superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities. Rats pretreated orally with essential oil of Thymus Capitatus and Salvia Officinal (50 mg/kg b. wt. daily) for 15 days then intoxicated with paracetamol showed a significant protection against-induced increase in serum and hepatic LDH activities and inhibit reduce GSH levels and enhance increase SOD and GPx activities in blood and liver. These data indicate that essential oils of Thymus Capitatus and Salvia Officinalis possessed a hepatoprotective activity against hepatotoxicity induced by paracetamol model due to their antioxidant activity.

Key words: Thymus, salvia, hepatoprotective, antioxidant.



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This Article Cited By the following articles

Prospective evaluation of potential toxicity of repeated doses ofThymus vulgarisL. extracts in rats by means of clinical chemistry, histopathology and NMR-based metabonomic approach
Drug Test. Analysis 2014; (): n/a.

1
 

How to Cite this Article
Pubmed Style

Banna HE, Soliman M, wabel Na. Hepatoprotective Effects of Thymus and Salvia Essential oils on Paracetamol-Induced Toxicity in Rats. J. Phys. Pharm. Adv.. 2013; 3(2): 41-47. doi:10.5455/jppa.20130228054608



Web Style

Banna HE, Soliman M, wabel Na. Hepatoprotective Effects of Thymus and Salvia Essential oils on Paracetamol-Induced Toxicity in Rats. www.scopemed.org/?mno=25791 [Access: November 26, 2014]. doi:10.5455/jppa.20130228054608



AMA (American Medical Association) Style

Banna HE, Soliman M, wabel Na. Hepatoprotective Effects of Thymus and Salvia Essential oils on Paracetamol-Induced Toxicity in Rats. J. Phys. Pharm. Adv.. 2013; 3(2): 41-47. doi:10.5455/jppa.20130228054608



Vancouver/ICMJE Style

Banna HE, Soliman M, wabel Na. Hepatoprotective Effects of Thymus and Salvia Essential oils on Paracetamol-Induced Toxicity in Rats. J. Phys. Pharm. Adv.. (2013), [cited November 26, 2014]; 3(2): 41-47. doi:10.5455/jppa.20130228054608



Harvard Style

Banna, H. E., Soliman, M. & wabel, N. a. (2013) Hepatoprotective Effects of Thymus and Salvia Essential oils on Paracetamol-Induced Toxicity in Rats. J. Phys. Pharm. Adv., 3 (2), 41-47. doi:10.5455/jppa.20130228054608



Turabian Style

Banna, Hossny El, Maher Soliman, and Naser al wabel. 2013. Hepatoprotective Effects of Thymus and Salvia Essential oils on Paracetamol-Induced Toxicity in Rats. Journal of Physiology and Pharmacology Advances, 3 (2), 41-47. doi:10.5455/jppa.20130228054608



Chicago Style

Banna, Hossny El, Maher Soliman, and Naser al wabel. "Hepatoprotective Effects of Thymus and Salvia Essential oils on Paracetamol-Induced Toxicity in Rats." Journal of Physiology and Pharmacology Advances 3 (2013), 41-47. doi:10.5455/jppa.20130228054608



MLA (The Modern Language Association) Style

Banna, Hossny El, Maher Soliman, and Naser al wabel. "Hepatoprotective Effects of Thymus and Salvia Essential oils on Paracetamol-Induced Toxicity in Rats." Journal of Physiology and Pharmacology Advances 3.2 (2013), 41-47. Print. doi:10.5455/jppa.20130228054608



APA (American Psychological Association) Style

Banna, H. E., Soliman, M. & wabel, N. a. (2013) Hepatoprotective Effects of Thymus and Salvia Essential oils on Paracetamol-Induced Toxicity in Rats. Journal of Physiology and Pharmacology Advances, 3 (2), 41-47. doi:10.5455/jppa.20130228054608



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