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Original Article



Clinico-Pathological Findings in Myeloid Malignancies: A Single Center Experience

Faheem Ahmed Memon, Amir Iqbal Memon, Pushpa, Nisar Ahmed, Roohi Nigar, Ikramdin Ujjan.

Abstract
INTRODUCTION: Myeloid malignancies are clonal disorders of hematopoietic stem/precursor cells. The
criteria for the diagnosis of acute myeloid leukemia (AML) are based on morphological cytogenetic and
flow-cytometric findings. The prognostic outcome with intensive chemotherapy is better than with
non-intensive treatment.
PURPOSE/OBJECTIVES: To determine the frequency of various clinical & pathological findings in
myeloid malignancies.
STUDY DESIGN: Cross sectional descriptive study.
PLACE AND DURATION OF STUDY: The study was carried out at Department of Pathology from October
2014 to December 2016.
MATERIAL/PATIENTS AND METHODS: Detailed history, clinical and pathological findings recorded on a
pre-designed proforma including bone marrow reports was evaluated.
RESULTS: During period of study, 351 proformas including bone marrow reports were evaluated, from
which 49 (30 males and 19 females; age ranges between 03 months to 60 years) were diagnosed as
myeloid malignancies. The distribution of myeloid malignancies were acute myeloid leukemia (n=21),
chronic myeloid leukemia (n=14), acute myelodysplastic syndrome (n=3), myeloproliferative neoplasms
(n=3), myelofibrosis (n=2), myeloid hyperplasia (n=2), acute promyelocytic leukemia (n=2),
myelomonocytic leukemia (n=1), ,and transient abnormal myelopoiesis (n=1).The main presenting
complaints were fever and weight loss, whereas splenomegaly was the most common finding on clinical
examination. The commonest laboratory finding was anemia followed by leukocytosis; while 10 patients
showed pancytopenia.
CONCLUSION: AML with fever and bicytopenia is the commonest myeloid malignancy in our series.

Key words: Acute myeloid leukemia, Myelodysplastic syndrome, splenomegaly.



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