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International Journal of Medical Science and Public Health
Periodical of Mrs. Deepika Charan
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ISSN: 2320-4664 (Print)
ISSN: 2277-338X (Online)
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Open Access

Original Research



Importance of cardiac marker enzymes (Aspartate transaminase and troponin I) in acute myocardial infarction: A case-control study from South India

Vuddandi Prabodh, Deva Prakash, Godi Sudhakar, Yeruva Reddy, Nadella Chowdary, Sripada Desai, Ravi Shekhara.

Cited by (4)

Abstract
Background: Cardiac marker enzymes are measured to evaluate the heart function. The diagnosis of acute myocardial infarction can be achieved by electrocardiogram (ECG) changes and elevation of cardiac marker enzymes like creatine kinase, lactate dehydrogenase (LDH), aspartate transaminase (AST) and troponin I.

Objective: To estimates the levels of AST and troponin I among patients of acute myocardial infarction, and to compare with those among health controls.

Materials and Methods: This study was carried out among 50 cases of acute myocardial infarction and 50 age and sex matched healthy individuals. Serum samples of cases, collected after 5 hours and within 24 hours from the onset of chest pain and of controls were analyzed for AST by modified IFCC method and for troponin I by chemiluminescence – sandwich method.

Results: The mean levels of AST and troponin I in cases and controls revealed that mean levels of AST and cardiac troponin I in cases (296.02±SD 135.69 IU/L and 57.34±SD 12.83 ng/ml, erspectively) are significantly higher than among controls (25.50±SD 6.22 IU/L and 0.31±SD 0.15 ng/ml, respectively). The differences between cases and controls are statistically significant (p<0.0001).

Conclusion: The diagnostic efficiency of AST and troponin I were superior because they are specific to myocardial injury.

Key words: Cardiac Enzymes; Aspartate Transaminase; Troponin I; Myocardial Infarction



REFERENCES



1. Lott JA. Serum enzyme determinations in diagnosis of acute myocardial infarction.an update. Human Pathology 1984;15:706-16.

http://dx.doi.org/10.1016/S0046-8177(84)80160-4


2. Rude RE, Poole WK, Muller JE, Turi Z, Rutherford J, Parker C, Roberts R, Raabe DS Jr, Gold HK, Stone PH, et al. Electrocardiographic and clinical criteria for recognition of acute myocardial infarction based on análisis of 3,697 pateints. Am J Cardiol 1983;52:936-42.

http://dx.doi.org/10.1016/0002-9149(83)90508-8


3. Nigam PK. Biochemical markers of myocardial injury. Indian J Clin Biochem 2007;22:10-17.

http://dx.doi.org/10.1007/BF02912874

[
Pubmed]    [PMC Free Fulltext]   

4. Sobel BE, Shell WE. Serum enzyme determinations in the diagnosis and assessment of myocardial infarction. Circulation 1972;45:471-79.

http://dx.doi.org/10.1161/01.CIR.45.2.471

[
Pubmed]   


5. Azzazy HM, Christenson RH. Cardiac markers of acute coronary syndrome. Clin Biochem 2002;35:13-27.

http://dx.doi.org/10.1016/S0009-9120(02)00277-1


6. Green GB, Green SF. Markers of myocardial injury in the evaluation of the emergency department patient with chest pain. In: Wu AHB, ed. Cardiac Markers. Totawa, NJ: Humana Press; 1998:75-89.

http://dx.doi.org/10.1007/978-1-4612-1806-7_4

[
Pubmed]   


7. Christenson RH, Azzazy HME. Biochemical markers of acute coronary syndromes. Clin Chem 1998;44;1855-64.

[
Pubmed]   


8. Burtis, CA. & Ashwood, ER. Tietz Textbook of Clinical Chemistry. 2nd ed. W. B. Saunders. 1994.


9. Boriani G, Biffi M, Cervi V, Bronzetti G, Magagnoli G, Zannoli R, Bransi A. Evaluation of myocardial injury following repeated internal atrial shocks by monitoring serum cardiac troponin I levels. Chest 2000;118;342-47.

http://dx.doi.org/10.1378/chest.118.2.342

[
Pubmed]   


10. Adams JE, Abendschein DR, Jaffe AS. Biochemical markers of myocardial injury: Is MB creatinine kinase the choice for the 1990s? Circulation 1993;88;750-763.

http://dx.doi.org/10.1161/01.CIR.88.2.750

[
Pubmed]   


11. Chiu A, Chan WK, Cheng SH, Leung CK, Choi CH. Troponin I, myoglobin and mass concentration of creatine kinase –MB in myocardial infarction. QJ Med 1999;92;711-18.

http://dx.doi.org/10.1093/qjmed/92.12.711


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How to Cite this Article
Pubmed Style

Prabodh V, Prakash D, Sudhakar G, Reddy Y, Chowdary N, Desai S, Shekhara R. Importance of cardiac marker enzymes (Aspartate transaminase and troponin I) in acute myocardial infarction: A case-control study from South India. Int J Med Sci Public Health. 2012; 1(2): 118-120. doi:10.5455/ijmsph.2012.1.118-120



Web Style

Prabodh V, Prakash D, Sudhakar G, Reddy Y, Chowdary N, Desai S, Shekhara R. Importance of cardiac marker enzymes (Aspartate transaminase and troponin I) in acute myocardial infarction: A case-control study from South India. www.scopemed.org/?mno=26718 [Access: August 24, 2016]. doi:10.5455/ijmsph.2012.1.118-120



AMA (American Medical Association) Style

Prabodh V, Prakash D, Sudhakar G, Reddy Y, Chowdary N, Desai S, Shekhara R. Importance of cardiac marker enzymes (Aspartate transaminase and troponin I) in acute myocardial infarction: A case-control study from South India. Int J Med Sci Public Health. 2012; 1(2): 118-120. doi:10.5455/ijmsph.2012.1.118-120



Vancouver/ICMJE Style

Prabodh V, Prakash D, Sudhakar G, Reddy Y, Chowdary N, Desai S, Shekhara R. Importance of cardiac marker enzymes (Aspartate transaminase and troponin I) in acute myocardial infarction: A case-control study from South India. Int J Med Sci Public Health. (2012), [cited August 24, 2016]; 1(2): 118-120. doi:10.5455/ijmsph.2012.1.118-120



Harvard Style

Prabodh, V., Prakash, D., Sudhakar, G., Reddy, Y., Chowdary, N., Desai, S. & Shekhara, R. (2012) Importance of cardiac marker enzymes (Aspartate transaminase and troponin I) in acute myocardial infarction: A case-control study from South India. Int J Med Sci Public Health, 1 (2), 118-120. doi:10.5455/ijmsph.2012.1.118-120



Turabian Style

Prabodh, Vuddandi, Deva Prakash, Godi Sudhakar, Yeruva Reddy, Nadella Chowdary, Sripada Desai, and Ravi Shekhara. 2012. Importance of cardiac marker enzymes (Aspartate transaminase and troponin I) in acute myocardial infarction: A case-control study from South India. International Journal of Medical Science and Public Health, 1 (2), 118-120. doi:10.5455/ijmsph.2012.1.118-120



Chicago Style

Prabodh, Vuddandi, Deva Prakash, Godi Sudhakar, Yeruva Reddy, Nadella Chowdary, Sripada Desai, and Ravi Shekhara. "Importance of cardiac marker enzymes (Aspartate transaminase and troponin I) in acute myocardial infarction: A case-control study from South India." International Journal of Medical Science and Public Health 1 (2012), 118-120. doi:10.5455/ijmsph.2012.1.118-120



MLA (The Modern Language Association) Style

Prabodh, Vuddandi, Deva Prakash, Godi Sudhakar, Yeruva Reddy, Nadella Chowdary, Sripada Desai, and Ravi Shekhara. "Importance of cardiac marker enzymes (Aspartate transaminase and troponin I) in acute myocardial infarction: A case-control study from South India." International Journal of Medical Science and Public Health 1.2 (2012), 118-120. Print. doi:10.5455/ijmsph.2012.1.118-120



APA (American Psychological Association) Style

Prabodh, V., Prakash, D., Sudhakar, G., Reddy, Y., Chowdary, N., Desai, S. & Shekhara, R. (2012) Importance of cardiac marker enzymes (Aspartate transaminase and troponin I) in acute myocardial infarction: A case-control study from South India. International Journal of Medical Science and Public Health, 1 (2), 118-120. doi:10.5455/ijmsph.2012.1.118-120



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News / Announcements

  • Retraction notice ['Mar 01, 2015']

  • Join IJMSPH as reviewer ['Jul 22, 2012']

  • Submission of article ['Jul 22, 2012']





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