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Original Article

Serum paraoxonase-1 activity in Egyptian premenopausal women with metabolic syndrome and its relation with recurrent pre-eclampsia risk

Walaa Basha, Walaa Yousef, Ahmed Ismail, Eman Younes, Tamer Hussein, Osama Azmy.

Background: Association of paraoxonase-1 (PON-1) with the metabolic syndrome (MS) and recurrent preeclampsia has not been previously investigated among Egyptian premenopausal women. Pre-eclampsia is a multisystem disorder and its etiopathogenesis has not yet been fully understood.
Aim: The aim of the study is to investigate serum PON-1 activity in Egyptian women with MS and assess its potential link with the incidence of recurrent pre-eclampsia.
Method: The study group consisted of 60 premenopausal women with MS and 60 healthy controls. In the MS group, 26 patients had past history of recurrent pre-eclampsia. The enzymatic activity of serum PON-1 was measured by spectrophotometer. Serum lipids were measured by enzymatic colorimetric methods using a Hitachi auto-analyzer.
Results: MS cases with and without recurrent pre-eclampsia showed significantly reduced PON-1 activity compared to healthy controls. Significant negative correlations were observed between PON-1 levels and BMI, SBP, DBP, serum total cholesterol, TG and LDL-C and positive correlation with HDL–C in MS cases either with or without recurrent pre-eclampsia. In addition, MS cases with history of recurrent pre-eclampsia showed significantly lower levels of PON-1 than those without.
Conclusions: Serum PON-1 is significantly reduced in women with MS and might alter their lipid profile. Low PON-1 levels could contribute to the great risk of recurrent preeclampsia in MS women.

Key words: Serum PON-1, metabolic syndrome, recurrent preeclampsia, serum lipids, women

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