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Medical Archives
Periodical of AVICENA, d.o.o., Sarajevo
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ISSN: 0350-199X (Print)
ISSN: 1986-5961 (Online)
Language: [ English ]  
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Open Access

Original Research



Betahistine or Cinnarizine for Treatment of Meniere’s Disease

Jasminka Djelilovic-Vranic, Azra Alajbegovic, Merita Tiric-Campara, Aida Volic, Zehra Sarajlic, Eldina Osmanagic, Ljubica Todorovic,Omer Beslagic.

Abstract
Introduction: Meniere’s disease is a condition with sudden attacks of vertigo with nausea and vomiting accompanied by loss of hearing and buzzing sensation in the ears, most commonly unilateral. The exact cause of the disease is unknown. Betahistine is the analogue of histamine with weaker agonistic effect on histamine H1 receptors and stronger effect on histamine H3 receptors, while Cinnarizine has more effective effect on H1 receptors. Goal: The aim is to determine which drug is more effective in the treatment of Meniere’s disease Betahistine or Cinnarizine. Material and methods: This study evaluates the effectiveness of Betahistine in 37 patients with the Meniere’s syndrome accompanied by classic triad of symptoms treated in hospital conditions and Cinnarizine effect in 36 patients with a less severe clinical picture, which were treated as outpatients. To all patients were conducted laboratory tests, brain CAT (to exclude possible expansive process, MS or stroke) and TCD in order to eliminate any possible circulatory disturbances in VB basin. Group with classic Meniere’s syndrome was treated at a dose of Betahistine of 3x16mg and followed 8 weeks, while the second group was treated with Cinnarizine at a dose of 2x75mg and also followed for 8 weeks. Conclusions: Already after one month of therapy was noticed better effect in case of Betahistine in terms of symptoms reduction compared to the Cinnarizine effect.

Key words: Betahistine, Cinnarizine, Meniere’s disease



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How to Cite this Article
Pubmed Style

Djelilovic-Vranic J, Alajbegovic A, Tiric-Campara M, Volic A, Sarajlic Z, Osmanagic E, Todorovic L, Beslagic O. Betahistine or Cinnarizine for Treatment of Meniere’s Disease . Med Arh. 2012; 66(6): 396-398. doi:10.5455/medarh.2012.66.396-398



Web Style

Djelilovic-Vranic J, Alajbegovic A, Tiric-Campara M, Volic A, Sarajlic Z, Osmanagic E, Todorovic L, Beslagic O. Betahistine or Cinnarizine for Treatment of Meniere’s Disease . www.scopemed.org/?mno=28940 [Access: October 22, 2014]. doi:10.5455/medarh.2012.66.396-398



AMA (American Medical Association) Style

Djelilovic-Vranic J, Alajbegovic A, Tiric-Campara M, Volic A, Sarajlic Z, Osmanagic E, Todorovic L, Beslagic O. Betahistine or Cinnarizine for Treatment of Meniere’s Disease . Med Arh. 2012; 66(6): 396-398. doi:10.5455/medarh.2012.66.396-398



Vancouver/ICMJE Style

Djelilovic-Vranic J, Alajbegovic A, Tiric-Campara M, Volic A, Sarajlic Z, Osmanagic E, Todorovic L, Beslagic O. Betahistine or Cinnarizine for Treatment of Meniere’s Disease . Med Arh. (2012), [cited October 22, 2014]; 66(6): 396-398. doi:10.5455/medarh.2012.66.396-398



Harvard Style

Djelilovic-Vranic, J., Alajbegovic, A., Tiric-Campara, M., Volic, A., Sarajlic, Z., Osmanagic, E., Todorovic, L. & Beslagic, O. (2012) Betahistine or Cinnarizine for Treatment of Meniere’s Disease . Med Arh, 66 (6), 396-398. doi:10.5455/medarh.2012.66.396-398



Turabian Style

Djelilovic-Vranic, Jasminka, Azra Alajbegovic, Merita Tiric-Campara, Aida Volic, Zehra Sarajlic, Eldina Osmanagic, Ljubica Todorovic, and Omer Beslagic. 2012. Betahistine or Cinnarizine for Treatment of Meniere’s Disease . Medical Archives, 66 (6), 396-398. doi:10.5455/medarh.2012.66.396-398



Chicago Style

Djelilovic-Vranic, Jasminka, Azra Alajbegovic, Merita Tiric-Campara, Aida Volic, Zehra Sarajlic, Eldina Osmanagic, Ljubica Todorovic, and Omer Beslagic. "Betahistine or Cinnarizine for Treatment of Meniere’s Disease ." Medical Archives 66 (2012), 396-398. doi:10.5455/medarh.2012.66.396-398



MLA (The Modern Language Association) Style

Djelilovic-Vranic, Jasminka, Azra Alajbegovic, Merita Tiric-Campara, Aida Volic, Zehra Sarajlic, Eldina Osmanagic, Ljubica Todorovic, and Omer Beslagic. "Betahistine or Cinnarizine for Treatment of Meniere’s Disease ." Medical Archives 66.6 (2012), 396-398. Print. doi:10.5455/medarh.2012.66.396-398



APA (American Psychological Association) Style

Djelilovic-Vranic, J., Alajbegovic, A., Tiric-Campara, M., Volic, A., Sarajlic, Z., Osmanagic, E., Todorovic, L. & Beslagic, O. (2012) Betahistine or Cinnarizine for Treatment of Meniere’s Disease . Medical Archives, 66 (6), 396-398. doi:10.5455/medarh.2012.66.396-398



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