Objective: To determine the in vitro susceptibility of MRSA clinical isolates to ceftaroline, using interpretation of
zones of inhibition by disk diffusion method.
Study Design: Descriptive cross sectional.
Place and Duration of Study: The study was carried out at the Department of Microbiology, Combined Military
Hospital Peshawar, from Jan to Dec 2014.
Material and Methods: To carry out this descriptive cross sectional study, clinical specimens were obtained from
indoor and outdoor patients of Combined Military Hospital Peshawar. All the isolates of MRSA cultured with
CLSI guidelines and identified with standard microbiological procedures, from clinical specimens of pus, body
fluid, urine, tissue and blood were included in the study. The antimicrobial susceptibility pattern of ceftaroline
was determined according to CLSI guidelines. The data was analyzed in SPSS (version 19) software.
Results: Out of a total 190 MRSA isolates, 183 (96.3%) were susceptible to ceftaroline in vitro, whereas 5 (2.6%)
were resistant and 2 (1.1%) were intermediate in their response to ceftaroline.
Conclusion: Ceftaroline can be used effectively against infections caused by MRSA as it has shown very high in
vitro activity against MRSA strains of clinical origin.
Antimicrobial susceptibility, Ceftaroline, MRSA.