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National Journal of Physiology, Pharmacy and Pharmacology
Periodical of Mrs Dipika Charan
Journal Home Page
ISSN: 2320-4672 (Print)
ISSN: 2231-3206 (Online)
Language: [ English ]  
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  » Volume 4, Issue 1
      pp. 1-98

 

Open Access

Original Research



Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark

Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma.

A B S T R A C T 

Abstract
Background: Most of the parts of neem tree were studied in details by many researchers but neem root bark was not screened for antidiabetic effect. To evaluate antidiabetic effect of neem root bark this study was conducted.

Aims & Objective: The present study was undertaken to evaluate the 70% alcoholic neem root bark extract (NRE) in diabetes.

Materials and Methods: Basal blood sugar levels were estimated in overnight fasted wistar albino rats of either sex. To evaluate antihyperglycemic action of Neem root bark extract (NRE) OGTT was done by giving glucose orally 60 minutes after giving standard drug (Glibenclamide),Test drug (NRE) in the dose of 200,400 and 800 mg/kg and blood sugar levels were estimated every half hourly up to 4 hours. To evaluate hypoglycemic activity in alloxan induced diabetic rats similar doses once daily for 15 days. Blood sugar levels were estimated by using glucometer.

Results: For glucose tolerance test Glibenclamide significant (p< 0.01) reduction in blood sugar levels. The NRE showed statistically significant results in only 800 mg/kg dose. In comparison to glibenclamide it did not show. In alloxan induced diabetes Glibenclamide showed significant (p<0.01) reduction in blood sugar levels. The NRE showed statistically significant results in only 800 mg/kg dose.

Conclusion: Neem root has antihyperglycemic and hypoglycemic activity. It is not as significant as glibenclmide.

Key words: Alloxan; Antihyperglycemic; Hypoglycemic; Neem Root Bark


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How to Cite this Article
Pubmed Style

Patil P, Patil S, Mane A, Verma S. Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark. Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146. doi:10.5455/njppp.2013.3.134-138



Web Style

Patil P, Patil S, Mane A, Verma S. Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark. www.scopemed.org/?mno=30622 [Access: April 23, 2014]. doi:10.5455/njppp.2013.3.134-138



AMA (American Medical Association) Style

Patil P, Patil S, Mane A, Verma S. Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark. Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146. doi:10.5455/njppp.2013.3.134-138



Vancouver/ICMJE Style

Patil P, Patil S, Mane A, Verma S. Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark. Natl J Physiol Pharm Pharmacol. (2013), [cited April 23, 2014]; 3(2): 142-146. doi:10.5455/njppp.2013.3.134-138



Harvard Style

Patil, P., Patil, S., Mane, A. & Verma, S. (2013) Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark. Natl J Physiol Pharm Pharmacol, 3 (2), 142-146. doi:10.5455/njppp.2013.3.134-138



Turabian Style

Patil, Prabhakar, Sudha Patil, Abhay Mane, and Sushilkumar Verma. 2013. Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark. National Journal of Physiology, Pharmacy and Pharmacology, 3 (2), 142-146. doi:10.5455/njppp.2013.3.134-138



Chicago Style

Patil, Prabhakar, Sudha Patil, Abhay Mane, and Sushilkumar Verma. "Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark." National Journal of Physiology, Pharmacy and Pharmacology 3 (2013), 142-146. doi:10.5455/njppp.2013.3.134-138



MLA (The Modern Language Association) Style

Patil, Prabhakar, Sudha Patil, Abhay Mane, and Sushilkumar Verma. "Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark." National Journal of Physiology, Pharmacy and Pharmacology 3.2 (2013), 142-146. Print. doi:10.5455/njppp.2013.3.134-138



APA (American Psychological Association) Style

Patil, P., Patil, S., Mane, A. & Verma, S. (2013) Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark. National Journal of Physiology, Pharmacy and Pharmacology, 3 (2), 142-146. doi:10.5455/njppp.2013.3.134-138




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  • Journal is Indexed in EMBASE ['Feb 15, 2013']

  • Hard copy of journal ['Feb 11, 2013']





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