Abstract
Mechanism-based classification (MBC) of pain comprised of five mechanisms: cognitive-affective, central sensitization, peripheral sensitization, sympathetically maintained pain, and nociceptive. The objective of this editorial was to provide an overview on central sensitization and its implications for PT evaluation and management of central sensitivity syndromes associated with common clinical presentations.

Key words: central sensitization, central sensitivity syndrome, central pain, cortical reorganization, pain science.