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International Journal of Basic & Clinical Pharmacology
Periodical of Medip Academy
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ISSN: 2319-2003 (Print)
ISSN: 2279-0780 (Online)
Language: [ English ]  
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Open Access

Original Research



Haemodynamic effects of intrathecal dexmedetomidine added to ropivacaine intraoperatively and for postoperative analgesia

Alka Shah, Ila Patel, Rachana Gandhi.

Abstract
Background: For lower abdomen and lower limb surgery, spinal anaesthesia is most common modality used in routine. This study was conducted on 50 ASA 1 and 2 planned for lower limb and lower abdomen surgery.
Methods: 50 patients of ASA 1 and 2 scheduled for lower limb and lower abdominal surgery were selected. Each patient received 4 milliliter volume of 0.75% isobaric ropivacaine + 5 microgram dexmedetomidine. At the intervals of 1 minute, 2 minute, 5 minute, 10 minute, 20 minute, 30 minute and 1 hour, 2 hour and 3 hour reading of pulse rate and blood pressure were recorded. Postoperatively, pain scores were recorded by using Visual Analogue Scale.
Results: There were no significant changes in systolic and diastolic blood pressure after induction. The combination of ropivacaine and dexmedetomidine provided better postoperative analgesia and reduced requirement of diclofenac injection in first 24 hour.
Conclusions: The patients showed excellent hemodynamic stability and postoperative analgesia to ropivacaine + dexmedetomidine. Thus it is a safe modality for lower limb and lower abdomen surgery as far as haemodynamic effects and postoperative analgesia is concerned.

Key words: Ropivacaine, Dexmedetomidine, Haemodynamic effects, Spinal block



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PMid:9357885

How to Cite this Article
Pubmed Style

Shah A, Patel I, Gandhi R. Haemodynamic effects of intrathecal dexmedetomidine added to ropivacaine intraoperatively and for postoperative analgesia. Int J Basic Clin Pharmacol. 2013; 2(1): 26-29. doi:10.5455/2319-2003.ijbcp20130105



Web Style

Shah A, Patel I, Gandhi R. Haemodynamic effects of intrathecal dexmedetomidine added to ropivacaine intraoperatively and for postoperative analgesia. www.scopemed.org/?mno=32060 [Access: September 16, 2014]. doi:10.5455/2319-2003.ijbcp20130105



AMA (American Medical Association) Style

Shah A, Patel I, Gandhi R. Haemodynamic effects of intrathecal dexmedetomidine added to ropivacaine intraoperatively and for postoperative analgesia. Int J Basic Clin Pharmacol. 2013; 2(1): 26-29. doi:10.5455/2319-2003.ijbcp20130105



Vancouver/ICMJE Style

Shah A, Patel I, Gandhi R. Haemodynamic effects of intrathecal dexmedetomidine added to ropivacaine intraoperatively and for postoperative analgesia. Int J Basic Clin Pharmacol. (2013), [cited September 16, 2014]; 2(1): 26-29. doi:10.5455/2319-2003.ijbcp20130105



Harvard Style

Shah, A., Patel, I. & Gandhi, R. (2013) Haemodynamic effects of intrathecal dexmedetomidine added to ropivacaine intraoperatively and for postoperative analgesia. Int J Basic Clin Pharmacol, 2 (1), 26-29. doi:10.5455/2319-2003.ijbcp20130105



Turabian Style

Shah, Alka, Ila Patel, and Rachana Gandhi. 2013. Haemodynamic effects of intrathecal dexmedetomidine added to ropivacaine intraoperatively and for postoperative analgesia. International Journal of Basic & Clinical Pharmacology, 2 (1), 26-29. doi:10.5455/2319-2003.ijbcp20130105



Chicago Style

Shah, Alka, Ila Patel, and Rachana Gandhi. "Haemodynamic effects of intrathecal dexmedetomidine added to ropivacaine intraoperatively and for postoperative analgesia." International Journal of Basic & Clinical Pharmacology 2 (2013), 26-29. doi:10.5455/2319-2003.ijbcp20130105



MLA (The Modern Language Association) Style

Shah, Alka, Ila Patel, and Rachana Gandhi. "Haemodynamic effects of intrathecal dexmedetomidine added to ropivacaine intraoperatively and for postoperative analgesia." International Journal of Basic & Clinical Pharmacology 2.1 (2013), 26-29. Print. doi:10.5455/2319-2003.ijbcp20130105



APA (American Psychological Association) Style

Shah, A., Patel, I. & Gandhi, R. (2013) Haemodynamic effects of intrathecal dexmedetomidine added to ropivacaine intraoperatively and for postoperative analgesia. International Journal of Basic & Clinical Pharmacology, 2 (1), 26-29. doi:10.5455/2319-2003.ijbcp20130105



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