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International Journal of Basic & Clinical Pharmacology
Periodical of Medip Academy
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ISSN: 2319-2003 (Print)
ISSN: 2279-0780 (Online)
Language: [ English ]  

  » Volume 5, Issue 4
      pp. 1156-1690
  » Volume 5, Issue 3
      pp. 546-1155
  » Volume 5, Issue 2
      pp. 229-545
  » Volume 5, Issue 1
      pp. 1-228

 

Open Access

Original Research



Immunomodulatory effects of fruits of Barringtonia racemosa Linn.

Prabhakar R. Patil, Mahesh R. Patil, Abhay Mane, Sudha Patil.

Cited by (1)

Abstract
Background: Barringtonia racemosa (B. racemosa) is used medicinally in treatment of diarrhoea, asthma, coughs, jaundice. It is also used as an analgesic and antipyretic. This plant has also significant anti-tumor activity. However, systematic evaluation of its immunomodulatory effects has not been reported. In present study the hydroalcoholic extract of fruits of B. racemosa has been evaluated for its immunomodulatory properties in animal models.
Methods: Extract of Fruits of B. racemosa was prepared from fruit powder and methanol by macerations and filtration. Healthy albino Wistar rats of either sex having 110-160 g body weight were used for this study. 1. Delayed type hypersensitivity reaction (DTH) using Sheep red blood cells (SRBCs): After immunization with SRBC effect of cyclophosphamide and hydroalcoholic extract of B. racemosa was seen on paw volume changes in rats challenged with SRBC by using digital Plethysmometer. 2. Humoral antibody response to SRBC: Animas were immunized with SRBC and treated with cyclophosphamide and hydroalcoholic extract of B. racemosa. Serum of these animals was observed for haemagglutination titer.
Results: Fruits extract at the dose of 5 mg/kg i.p. showed significant decrease in DTH response as compared to that of control group animals. However, the effect of extract was less potent as compared to that of cyclophosphamide treated group. In haemagglutination titer assay, antibody titer in case naïve control, SRBC treated, cyclophosphamide treated and extract treated groups was 1:1, 1:32, 1:8 and 1:16 respectively.
Conclusions: The hydroalcoholic extract of this fruits was found to inhibit SRBCs induced DTH in rats. Similarly, SRBCs induced antibody titer was also reduced.

Key words: Barringtonia racemosa, Immunomodulation, Humoral immunity, Cellular immunity



REFERENCES
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1. Khan S, Jabbar A, Hasan CM, Rashid MA. Antibacterial activity of Barringtonia racemosa. J Ethnopharmacol 2001;72:162-4.


2. Deraniyagala SA, Ratnasooriya WD, Goonasekera CL. Antinociceptive effect and toxicological study of the aqueous bark extract of Barringtonia racemosa on rats. J Ethnopharmacol 2003;86:21-6.

http://dx.doi.org/10.1016/S0378-8741(03)00015-1


3. Thomas TJ, Panikkar B, Subramoniam A, Nair M, Panikkar KR. Antitumor property and toxicity of Barringtonia racemosa roxb seed extract in mice. J Ethnopharmacol 2002;82:223-7.

http://dx.doi.org/10.1016/S0378-8741(02)00074-0


4. Makare N, Bodhankar S, Rangari V. Immunomodulatory activity of alcoholic extract of Mangifera indica L. in mice. J Ethnopharmacol 2001;78:133-7.

http://dx.doi.org/10.1016/S0378-8741(01)00326-9


5. Agarwal R, Diwanay S, Patki P, Patwardhan B. Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation. J Ethnopharmacol 1999;67:27-35.

http://dx.doi.org/10.1016/S0378-8741(99)00065-3


6. Moudgil KD, Singh KA. Agglutinaton Methods. In: Talwar GP, Gupta SK, Editors, A Handbook of practical and clinical immunology. Vol-I, 2nd edition, CBS distributors, New Delhi; 1997: p.199.


7. Gupta SK. Production of murine Monoclonal antibodies. In: Talwar GP, Gupta SK, Editors, A Handbook of practical and clinical immunology Vol-I, 2nd edition, CBS distributors, New Delhi; 1997: p. 99.


8. Bin-Hafeez B, Haque R, Parvez S, Pandey S, Sayeed I, Raisuddin S. Immunomodulatory effects of fenugreek (Trigonella foenum graecum L.) extract in mice. Int J Immunopharmacol 2003;3:257-65.

http://dx.doi.org/10.1016/S1567-5769(02)00292-8


9. Damre AS, Gokhale AB, Phadke AS, Kulkarni KR, Saraf MN. Studies on the immunomodulatory activity of flavonoidal fraction of Tephrosia purpurea. Fitoterapia 2003;74:257-61.

http://dx.doi.org/10.1016/S0367-326X(03)00042-X


10. Tiwari U, Rastogi B, Thakur S, Jain S, Saraf DK. Studies on the immunomodulatory effects of Cleome viscose. Indian J Pharm Sci 2004;66:171-6.


11. Mediratta PK, Sharma KK, Singh S. Evaluation of immunomodulatory potential of Ocimum sanctum seed oil and its possible mechanism of action. J Ethnopharmacol 2002;80:15-20.

http://dx.doi.org/10.1016/S0378-8741(01)00373-7


12. Pallabi DE, Dasgupta SC, Gomes A. Immunopotentiating and immunoprophylactic activities of immune 21, a polyherbal product. Indian J Pharmacol 1998;30:163-8.


13. Shinde UA, Phadke AS, Nair AM, Mungantiwar AA, Dikshit VJ, Saraf MN. Preliminary studies on the immunomodulatory activity of Cedrus deodara wood oil. Fitoterapia 1999;70:333-9.

http://dx.doi.org/10.1016/S0367-326X(99)00031-3


14. Ghazanfari T, Zuhair H, Marzieh E. Immunomodulatory activity of a protein isolated from garlic extract on delayed type hypersensitivity. Int J Immunopharmacol 2002;2:1541-9.

http://dx.doi.org/10.1016/S1567-5769(02)00052-8

copyright 2002, pila, inc. all rights reserved

This Article Cited By the following articles

Immunomodulatory activity of kaempferol 5-O-β-d-glucopyranoside from Indigofera aspalathoides Vahl ex DC. (Papilionaceae)
Med Chem Res 2015; (): .

1
 

How to Cite this Article
Pubmed Style

Patil PR, Patil MR, Mane A, Patil S. Immunomodulatory effects of fruits of Barringtonia racemosa Linn.. Int J Basic Clin Pharmacol. 2013; 2(2): 216-219. doi:10.5455/2319-2003.ijbcp20130318



Web Style

Patil PR, Patil MR, Mane A, Patil S. Immunomodulatory effects of fruits of Barringtonia racemosa Linn.. www.scopemed.org/?mno=32297 [Access: July 28, 2016]. doi:10.5455/2319-2003.ijbcp20130318



AMA (American Medical Association) Style

Patil PR, Patil MR, Mane A, Patil S. Immunomodulatory effects of fruits of Barringtonia racemosa Linn.. Int J Basic Clin Pharmacol. 2013; 2(2): 216-219. doi:10.5455/2319-2003.ijbcp20130318



Vancouver/ICMJE Style

Patil PR, Patil MR, Mane A, Patil S. Immunomodulatory effects of fruits of Barringtonia racemosa Linn.. Int J Basic Clin Pharmacol. (2013), [cited July 28, 2016]; 2(2): 216-219. doi:10.5455/2319-2003.ijbcp20130318



Harvard Style

Patil, P. R., Patil, M. R., Mane, A. & Patil, S. (2013) Immunomodulatory effects of fruits of Barringtonia racemosa Linn.. Int J Basic Clin Pharmacol, 2 (2), 216-219. doi:10.5455/2319-2003.ijbcp20130318



Turabian Style

Patil, Prabhakar R., Mahesh R. Patil, Abhay Mane, and Sudha Patil. 2013. Immunomodulatory effects of fruits of Barringtonia racemosa Linn.. International Journal of Basic & Clinical Pharmacology, 2 (2), 216-219. doi:10.5455/2319-2003.ijbcp20130318



Chicago Style

Patil, Prabhakar R., Mahesh R. Patil, Abhay Mane, and Sudha Patil. "Immunomodulatory effects of fruits of Barringtonia racemosa Linn.." International Journal of Basic & Clinical Pharmacology 2 (2013), 216-219. doi:10.5455/2319-2003.ijbcp20130318



MLA (The Modern Language Association) Style

Patil, Prabhakar R., Mahesh R. Patil, Abhay Mane, and Sudha Patil. "Immunomodulatory effects of fruits of Barringtonia racemosa Linn.." International Journal of Basic & Clinical Pharmacology 2.2 (2013), 216-219. Print. doi:10.5455/2319-2003.ijbcp20130318



APA (American Psychological Association) Style

Patil, P. R., Patil, M. R., Mane, A. & Patil, S. (2013) Immunomodulatory effects of fruits of Barringtonia racemosa Linn.. International Journal of Basic & Clinical Pharmacology, 2 (2), 216-219. doi:10.5455/2319-2003.ijbcp20130318



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