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BMMR. 2010; 13(2): 47-50


Immunoadsorption in Highly-Sensitized Kidney Transplant Recipients

Ioannis Griveas, Georgios Visvardis, L Skoura, A Iniotaki, D Papadopoulou, G Sakellariou.

Abstract
Patients suffering from chronic renal insufficiency, who need to be treated with dialysis, are generally heavily impaired due to the regular, long lasting treatments. One way to escape this si- tuation is renal transplantation. However, patients with multiple blood transfusions or previous preg- nancies are often sensitized, leading to a poor prog- nosis of the immunologic acceptance of the donor organ. To enable even these patients to be trans- planted with an improved prognosis, besides immunosupression, the treatment with procedures of immunoadsorption is a promising therapy option. Four highly sensitized patients were treat- ed with immunoadsorption (2 men/2 women, range of age: 22-49 years). All patients were previously treated with renal transplantation. We noticed sig- nificant reduction in Panel Reactive Antibodies (PRA) from 68% (50%-80%) before the beginning of treatment to 2% (0%-5%) after the end of them. In spite of limited experience, immunoadsorption can safely and effectively remove anti-HLA in End-Stage Renal Failure patients.

Key words: Immunoadsorption, kidney trans- plantation, renal insufficiency



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