Home    eJManager.com Add Your Journal   |    Follow on Twitter   |    Subscribe to List

Directory for Medical Articles
 

Open Access

Original Research

SEAJCRR. 2013; 2(4): 218-228


Efficacy and Cost Effectiveness of Therapeutic Plasma Exchange in patient of Guillain-Barre Syndrome – A Prospective study

Dr. M. D. Gajjar, Dr. Sangita D. Shah, Dr. Mamta C.Shah, Dr. Nidhi M. Bhatnagar, Dr. Shital Soni, Dr.Tarak Patel.

Abstract
Introduction: Guillain-Barre syndrome (GBS) is an acute, frequently severe, fulminant poly-radiculoneuropathy that is autoimmune in nature. Current treatment modalities include therapeutic plasma exchange (TPE) and high dose intravenous Immunoglobulin therapy (I.V Ig), both of which involve a high cost. Objectives: To compare the cost effectiveness of plasma exchange over other modalities and to evaluate the clinical benefits of plasma exchange GBS patients. Discussion: In the present study, 100 patients (56 males and 44 females) admitted to the Civil Hospital, Ahmedabad from September 2010 to August 2012 with clinical findings of GBS and/or GBS variants were evaluated. Plasma was exchanged using a Baxter-CS 3000 continuous flow cell separator using double lumen femoral catheter, until a plasma discard of 50ml/kg had been achieved. Cost of treatment with plasma exchange for each patient was compared with other available modalities. Incidence of GBS was found to be more in 11-30 years age group. Male to female ratio was 1.27: 1. Most of the patients underwent 3 cycles of exchange. The result of plasma exchange in terms of improvement in clinical condition of patient was Excellent i.e. more than 85% in 82 patients. No complication was seen in 62 patients and minor complications were observed in 21 patients. The cost of plasma exchange and immunoglobulin treatment were came out to be approximately Rs 30,000/- and Rs. 1, 74,000/- in each patient respectively. Conclusion: Plasma exchange proved to be a better and less costly in the treatment of GBS patient if performed in the first two weeks of onset.

Key words: Guillain-Barre syndrome (GBS), Therapeutic Plasma Exchange (TPE), Intravenous Immunoglobulin (IV Ig)



Share this Article




ScopeMed Home
Follow ScopeMed on Twitter
Article Tools
Job Opportunities/Service Offers
eJManager OJMS
eJPort Journal Hosting
About ScopeMed
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Service of eJManager LLC Publishing for Scientific Publications. Copyright © ScopeMed® Information Services.
Scopemed Buttons