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NMJ. 2013; 2(1): 31-39


A study on anti hyper lipidemic effect of oral administration of cardamom in wistar albino rats.

Kumar Sai Sailesh* Divya** Mukkadan J.k***.

Abstract
Abstract
Background:
Currently, a number of synthetic hypolipidemic drugs are available and are effective but the associated side effects such as diarrhea, nausea, myositis and abnormal liver function severely handicap their application. Some patients are resistant to or are intolerant of conventional pharmacotherapy. Therefore, alternative approaches are eagerly needed, and plant-based therapies attract much interest, as they are effective in reducing lipid levels and show minimal or no side effects
Aims:
To evaluate the anti hyperlipidemic activity of oral administration of cardamom extract.
Methodology:
A total of 18 adult male and female Wistar rats, weighing 150-200g, and 60 days of age were selected for this study and divided into three groups with 6 rats in each group. Control group rats received only Rodent chow& water. Hyperlipedimic group received high fat diet and water. Cardamom group received high fat diet and water + Cardamom extract. Blood samples are collected from caudal vein at the tail tip to estimate total cholesterol, HDL, LDL and VLDL and triglycerides.
Results:
Oral administration of Cardamom extract significantly (p < 0.001) reduced total cholesterol, HDL, LDL and VLDL and triglycerides.
Conclusion:
From this study, we can conclude that the oral administration of cardamom extract have benefitial effects on blood cholesterol, triglyceride, VLDL, HDL and LDL levels. However further pharmacological and biochemical investigations will clearly elucidate the mechanism of action and helpful in projecting these plant extracts as a therapeutic target in diabetes research.

Key words: Anti hyper lipidemic effect, cardamom extract.



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