Background: The incidence of breast cancer has been increasing in India in the past few years. Oxidative stress is considered to be implicated in the pathophysiology of breast cancers. In normal conditions, a balance between the oxidants and their destruction by the cellular antioxidant system in the human body is maintained. However, any imbalance between the levels of oxidants and antioxidants might cause DNA damage and may lead to tumor development. Though a large number of women are affected with breast tumors, very few studies have been undertaken in India to compare oxidant/ antioxidant status in benign and malignant breast tumors. Therefore the present study was undertaken with following aim.
Aim: To compare the oxidative stress and dietary antioxidants in benign and malignant breast tumors.
Material and Methods: This study included clinically diagnosed and histopathologically proven 30 each benign and malignant breast tumor patients of stage III and IV as per inclusion criteria. Fresh tumor and fibro adenoma tissues were obtained from patients immediately after surgery. Adjacent normal tissue served as control. The levels of malondialdehyde [MDA]) as a marker of oxidative damage and dietary antioxidants (Vitamin A, E and C) were estimated from the benign, malignant and normal tissues.
Results: Significantly increased levels of MDA and decreased levels of dietary antioxidants (Vit E, C, A) were observed in benign and malignant breast tissue as compared to control tissue. A strong negative correlation in MDA Vs all vitamins were found.
Conclusion: The results of our study indicate that the imbalance between oxidants and antioxidants leads to oxidative stress which might be playing an important role in tumorogenesis.
Oxidative stress, dietary antioxidants, breast tumors