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Sublethal Dose of Diazinon Induces Pulmonary Toxicity in Rat: Histopathological Evidence

Gholamreza Najafi, Ali Asghar Tehrani, Ali Shalizar Jalali, Mohammad Babaei, Ali Najafi.

Abstract
Objective: Diazinon (DZ) is a widely used contact organophosphorous pesticide with broad spectrum insecticide activity. The extensive use of DZ has caused great concern due to the hazardous side effects on human beings as well as wild and domestic animals. The aim of this study was to investigate the effect of sublethal dose of DZ on rat lung.
Material and methods: Seven groups of male Wistar rats were used comprising control and test groups. The control group received corn oil (0.3 ml/day) for 60 days by oral gavages. The test groups received DZ at a dose of 60 mg/kg body weight orally for 2, 10, 24, 30, 54 and 60 days, respectively.
Results: The histopathological analysis of the lungs in DZ-treated groups revealed congestion on day 2, pulmonary edema and emphysema on day 10, congestion and atelectasia on day 24, infiltration of mononuclear cells on day 30 and pulmonary hemorrhage along with bronchial glands hyperplasia on days 54 and 60. DZ administration also caused a significant decrease in serum cholinesterase activity in a time-dependent manner.
Conclusion: These findings indicate that sublethal dose of DZ can induce severe lesions in the lung of rat.

Key words: Sublethal, Diazinon, Rat, Lung, Histopathology



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