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Topically Applied Tetrapleura tetraptera Stem-Bark Extract Promotes Healing of Excision and Incision Wounds in Rats

David Emery Tsala, Solomon Habtemariam, Foyet Harquin Simplice, Martin Thierry Bella Ndzana, Abraham Abraham Jital, Theophile Dimo.

Abstract
Objective. The objective of the present study was to evaluate the in vivo wound healing effect of water extract of Tetrapleura tetraptera in stem-bark. Method: The healing activity was studied in 40 male rats using excision and incision wounds on normal and dexamethasone-suppressed wound healing. For each model, rats were divided in 4 groups as follows: control, dexamethasone, T. tetraptera and dexamethasone combined with T. tetraptera. Results: Data recorded exhibited a significant effect by the extract in the epithelialization time within 14 and 18 days of the normal and dexamethasone-induced healing delay rats respectively (p

Key words: Tetrapleura tetraptera, skin, excision wound, incision wound, epithelialization, tensile strength


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