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RMJ. 2004; 29(1): 1-2

What to do with the fatty liver

Nasir Khokhar.

Ever since the first description, quarter of century ago (1), nonalcoholic fatty liver disease (NAFLD) is being increasingly recognized as a condition that may progress to end stage liver disease. There are many risk factors for the development of fatty liver (2). However, diabetes mellitus, obesity and hyperlipidemia have been the most commonest seen (2,3). NAFLD is prevalent worldwide with varying degrees in various countries and has ranged from 10-24 % in general population and nearly 75% in obese patient (4). It is becoming more common as obesity becomes a major medical problem (5). NAFLD is found in both sexes but women have been noted to be victim of this condition more often (2). The natural history is not as benign as once was thought to be, as more and more cases of cryptogenic cirrhosis have been attributed to fatty liver (6) and end stage liver with increased mortality (7) and even liver cancer has been associated with this (8).

Key words: NAFlD, NASH, Fatty liver, hepatic steatosis

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