ScopeMed - RSShttp://www.scopemed.orgScopeMed RSSen-us Copyright © 2011 ScopeMed All rights reserved. ScopeMedhttp://www.scopemed.org/img/logo-scopemed-ttk.gifhttp://www.scopemed.org 2015-03-31T16-50-59Z The Frequency of KISS1 Inactivating Mutation at Male Hypogonadotropic Hypogonadizm and Its Relationship with Hypothalamic- Pituitary- Gonad Axis http://www.scopemed.org/?mno=174050 2015-03-31T16-51-00Z
Source: Gulhane Medical Journal
Eylem ÇAĞILTAY, Mustafa KAPLAN, İsmail YILMAZ, Murat Hakan TEREKECİ, Ferhat DENİZ, Arif YÖNEM, Cihan TOP.
Aim: The aetiology of Idiopathic Hypogonadotropic Hypogonadism (IHH) has not been clearly understood. Gonadotropin Releasing Hormone (GnRH) is the major regulator of pituitary gonadotrophins (FSH and LH). GnRH secretion is regulated by some hormonal factors coming from other parts of hypotalamus and some other areas. One of the factors regulating GnRH secretion is kisspeptin. Recently, some studies have shown that kisspeptin mutations may have a role at the aetiology of IHH. In our study, we have measured the frequency of inactivating KISS1 mutation at the male IHH patients. Material and Methods: In this study, we have included 50 male IHH patients. Using the DNA samples gathered by genomic DNA extraction technique from the lymphocyte and granulocyte of the blood samples of IHH patients, we have proliferated the 3. exon region of the gene by PCR technique to detect KISS1 mutations with reverse and forward primers. The mutation analyses have been made with sequence analysis. Results: We have not detected an nucleotid differantiation (KISS1 Inactivating Mutation) after reverse and forward reading of 3. Exon region of the KISS1 gene that contains the mutation the at the 50 patients in our study group. Conclusion: This mutation that has been identified at female IHH, has not been detected in our male IHH study group. It can be concluded that this finding is because of the the rarity of this spesific mutation. We think that new and more expanded studies should be build for clearly identifying the molecular causes of IHH.
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Tue, 31 Mar 2015 13:34:04 GMT -08:00 http://www.scopemed.org/?mno=174050
Defining The Suitable Medical Emergency Code System For Gulhane Military Medical Faculty Training Hospital http://www.scopemed.org/?mno=48466 2015-03-31T16-51-00Z
Source: Gulhane Medical Journal
Necati Salman, Mehmet Eryılmaz, Murat Durusu, Yusuf Emrah Eyi, Ümit Kaldırım, Bülent Atik.
Our work’s aim is detecting the medical urgent condition code systems that we are planning to practice at Gulhane Military Medical Faculty Training Hospital, and revealing the personnel’s condition of preparedness. In the study, a survey is conducted to 200 participators from 4 different occupational groups and a drill is done to evaluate the in-hospital medical emergency ambulance team's response time. In consequence of the study, the attendance ratio is found to be low in the courses of cardiopulmonary resuscitation applications. By evaluating “first savior” cardiopulmonary resuscitation numbers in the last 1 year accordingly the occupational groups, it is suggested that nurses should be come into prominence during the applications in the hospital. It is put forward that cardiopulmonary resuscitation medicine and equipments are not present in sufficient amount in hospital clinics and some proportion of the participators do not have the enough experience to use of the stated medicines and equipments. In consequence of the study, when compared with the other medical emergency cases, it is primarily suggested that the response procedure for the existing cardiopulmonary arrest cases should be improved in the way that it covers all in-hospital arrest cases and uses existing in-hospital emergency ambulance facilities.
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Tue, 31 Mar 2015 13:33:27 GMT -08:00 http://www.scopemed.org/?mno=48466
The Impact of Mobile Devices on Healthcare in Rehabilitation Medicine http://www.scopemed.org/?mno=183752 2015-03-31T16-51-00Z
Source: International Journal of Health and Rehabilitation Sciences (IJHRS)
Landon R. Bulloch, Caroline Andrews, Taylor Dennison, Jordan Elder, Ashley Mitchell, Meredith T. Rivenbank, Kayla J. Schiling, and Vincent S. Gallicchio.
Background: In today’s changing world technological advances are not in short supply. One of the most important areas where technological advances can be seen is in the healthcare field. Advances in mobile device technology (hand-held devices, smartphones, iPads etc.) have the potential to change healthcare radically. Recent studies have implicated utilizing mobile device technologies have the capacity to lower the cost of healthcare while also improving the quality of healthcare received by patients. However, with this trend in place, there is currently an observed lack of usage of these advances in healthcare delivery and practice. Objectives: The aim of this study was to investigate the impact of wire-less devices and mobile technology on the rehabilitation science profession by soliciting input and feedback directly from rehabilitation science trained health care practitioners Materials and Methods: In order to gain insight why these technologies are not being used and/or not utilized to their full potential, a survey was created to assess the views of healthcare practitioners on mobile device technologies. This survey targeted the field of rehabilitation medicine with responders including physical and occupational therapists, and rehabilitation focused physicians. Results: Surveys analyzed from rehabilitation practitioners demonstrated overwhelming support in the use of mobile devices. The survey found there was concerns by practitioners over the potential lack of privacy patients may experience when viewing electronic records over a mobile device. The survey also exposed the lack of information within rehabilitation practitioners concerning the costs of utilizing mobile devices. Conclusion: The impact of mobile devices in various healthcare fields including rehabilitation science will continue to evolve in the effort to support the use of mobile device technologies and by doing so to improve the quality of healthcare experienced by all.
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Tue, 31 Mar 2015 11:07:31 GMT -08:00 http://www.scopemed.org/?mno=183752
A Scenario of Serum TNF α and C – Reactive Protein in Acute Ischemic Stroke and their Prognostic Significance http://www.scopemed.org/?mno=183751 2015-03-31T16-51-00Z
Source: International Journal of Health and Rehabilitation Sciences (IJHRS)
Zainab Yaseen, Sarita Agarwal, Manjula Shantaram, Debasish Chowdhury.
Background: Ischemic stroke comprises 85% of all stroke cases. Stroke is the third major cause of mortality worldwide and an important cause of long term disability contributing to major economic burden in most of the countries. Since inflammatory response is a key factor for ischemic damage of neurons, the markers of inflammation are supposed to have some predictive value in outcome of the ischemic stroke patients. Objective: The purpose of this study was to estimate the biochemical markers of inflammation and atherosclerosis (CRP and TNFα) in acute ischemic stroke patients and compare them with controls. Also to correlate these parameters with stroke severity, short term outcome after 7 days and long term outcome at 6 months using modified Rankin scale and Barthel Index. Method and Material: The present study was conducted on 45 acute ischemic stroke patients and 80 age and sex matched. The biochemical markers of inflammation and atherosclerosis (CRP and TNFα) in acute ischemic stroke patients were estimated and compared with controls. These parameters were analyzed for correlation with stroke severity (NIHSS), short term outcome after 7 days and long term outcome at 6 months using modified Rankin scale, Barthel Index and DWI MRI volume of infarct. The first blood sample was taken within 72 hours of onset of stroke and second sample was taken 7 days following the first sampling Results: Broadly the results showed that CRP and TNF α levels on the day of admission were higher in the experimental group as compared to controls. Difference was statistically significant. After 7 days, the levels of serum CRP and TNF α were high when compared to controls, however, the difference between day 1 and day 7 were not found to be statistically significant. When the biochemical parameters were correlated with the severity of stroke in NIHSS score, it was found that CRP on the day of admission and around 7th day correlated significantly with the severity of stroke assessed on both occasions. Correlating with the DWI MRI, volume of infarct, it was found that CRP on the day of admission as well as after 7 days correlated with the volume of infarct, therefore CRP levels correlate with the extent of tissue damage following ischemia. TNFα level did not correlate with the volume of infarct. CRP levels around 7th day also correlated with short term and long term outcome of patients assessed by modified Rankin scale and Barthel Index. Conclusion: Measuring CRP around one week following the stroke has the greatest prognostic value.
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Tue, 31 Mar 2015 10:43:42 GMT -08:00 http://www.scopemed.org/?mno=183751
APPROACH TO SYNCOPE IN EMERGENCY DEPARTMENT http://www.scopemed.org/?mno=164924 2015-03-31T16-51-00Z
Source: Turkish Journal of Family Medicine & Primary Care
fatma yiğit.
ABSTRACT Syncope, with the absence of postural tone, a sudden and transient loss of consciousness is characterized by full and often rapid spontaneous recovery. Most of the potential causes of syncope are benign and self-limiting. However, Syncope can be life-threatening causes. Approximately one third of patients during episodes of syncope cause injuries and can be psychologically devastating for patients with recurrent syncope. History, physical examination, and electrocardiogram can be detected an underlying cause in about 50 to 80% of patients. Despite detailed diagnostic tests, reason of syncope is undetectable in 18-41% of patients with syncope. This article is based on the problems of diagnostic approach to syncope in emergency department.
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Tue, 31 Mar 2015 08:42:51 GMT -08:00 http://www.scopemed.org/?mno=164924
ASSESSMENT OF ETIOLOGIC FACTORS IN CHILDREN WITH ATTENTION DEFICIT HYPERACTIVITY DISORDER: SERUM LEVELS OF BORON AND SELENIUM http://www.scopemed.org/?mno=166446 2015-03-31T16-51-00Z
Source: Turkish Journal of Family Medicine & Primary Care
Elif Deniz Safak, Mumtaz M. Mazicioglu, Ugur Sahin, Selcuk Mistik, Hasan Basri Ustunbas.
Objective: We aimed to determine the role of trace elements; selenium and boron levels in children and adolescents who have Attention Deficit Hyperactivity Disorder (ADHD). Material-Method: The study group consisted of 30 children who were diagnosed as ADHD according to DSM-IV criteria and compared with 20 healthy children who do not have ADHD. The study and control groups were given to fill a questionnaire which consists of 30 questions for screening socio-demographic data age, gender, prenatal, natal and postnatal trauma history, having any toxic-metabolic condition or infection, familial history of ADHD and psychiatric disorders. Turgay’s DSM-IV-Based Child and Adolescent Behavioral Disorders Screening and Rating Scale (T-DSM-IV-S), Conners’ Teacher Rating Scale, Conners’ Parent Rating Scale, Kiddie schedule for affective disorders and schizophrenia-present and lifetime version (K-SADS-PL), and Wechsler Intelligence Scale for Children-Revised (WISC-R) were used to diagnose ADHD. Serum selenium and boron levels were measured with the atomic absorption spectrophotometry. Result: All the scores of scales rating the ADHD symptoms of the children in the study group were significantly higher than in the controls. A statistically significant decrease in the serum selenium and boron levels was detected in children with ADHD. Conclusion: One of the important mechanisms in ADHD etiology is brain damage. Deficiency in the level of selenium and boron entering into the structure of the antioxidant enzyme system can lead to ADHD and other psychiatric disorders by damage to the brain tissue related to free radicals.
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Tue, 31 Mar 2015 08:42:51 GMT -08:00 http://www.scopemed.org/?mno=166446
Determination of food preparation and consumption to working and non-working Women. http://www.scopemed.org/?mno=166516 2015-03-31T16-51-00Z
Source: Turkish Journal of Family Medicine & Primary Care
Pınar Sökülmez Kaya.
Aim: working and non-working women food preparation and consumption of food ready at home to determine their status in Samsun. Material and methot: This survey includes 167 women(76 working,91 non-working) . 76 of them don’t have a job and 91of them have a job. Women food preparation, cooking, storage, query the status questionnaire was administered. The results was evaluated by using SPSS 21.0, percents and Chi Square test were used. In all tests, P
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Tue, 31 Mar 2015 08:42:51 GMT -08:00 http://www.scopemed.org/?mno=166516
THE RELATIONSHIP OF SERUM MELATONIN LEVELS WITH INFANTILE COLIC http://www.scopemed.org/?mno=168470 2015-03-31T16-51-00Z
Source: Turkish Journal of Family Medicine & Primary Care
Nihat Cengiz, Salim Özenç, Necati Balamtekin, Ali Erkan Sarı, Emin Özgür Akgül, Turgut Topal, Halil İbrahim Aydın, Mehmet Saldır, Ahmet Emin Kürekçi.
Abstract Background: The serotonin concentration peaks at night which causes intestinal cramps. Both serotonin and melatonin have circadian rhythms and they peak at night. While there are only serotonin circadian rhythms during birth, the melatonin circadian rhythms begin after 3rd month. It is argued that serotonin is high and melatonin is low for the infants who have colic, yet there are no studies proving this argument. Methods: The study population is chosen with a developed random sampling method among 50 infants who have infantile colic and 66 infants as healthy control group. Results: The melatonin levels of the blood samples are taken from both groups at 09.00 am and also from 20 infants with infantile colic blood samples were taken 09.00 pm. The melatonin level of the infants who have infantile colic wasfound lower than the control group (P: 0.014). The evening melatonin levels in babies with infantile colic were significantly higher compared to the morning levels (P < 0.001). Conclusions: Serum melatonin levels of the group under study have been found to be statistically significantly lower than the control group.The results of our study support the hypothesis that the decrease of melatonin level causes infantile colic
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Tue, 31 Mar 2015 08:42:51 GMT -08:00 http://www.scopemed.org/?mno=168470
MIGRAINE PREVALENCE AND RELATED FACTORS IN WESTERN ANATOLIA MIGRAINE PREVALANCE http://www.scopemed.org/?mno=169793 2015-03-31T16-51-00Z
Source: Turkish Journal of Family Medicine & Primary Care
Aysegul Uludag, Erkan Melih Sahin, Sibel Cevizci, Bulut Batu, Ozgur Guzey, Utku Petricli, Meryem Askın, Levent Seyhan, Demet Ozkan, Nezir Isleyen, Kadir Arslan, Sedat Yelpaze.
Background: Due to the severity of pain, effect on quality of life, and economic effects to individuals and society, migraine is a significant public health problem. We aimed to determine prevalence, socio-demographic characteristics and risk factors of migraine in western Anatolia. Method: In this cross-sectional, descriptive study, total of 942 volunteer participants in the age of 18-89, living in the center of Canakkale Western Anatolia, were enrolled from the nine primary care centers. We enrolled a questionnaire that asking about their socio-demographic features and the ID-Migraine Screening Test was administered. The participants answering the ID-Migraine test were questioned about characteristics of headache, triggering factors and accompanying complaints along with loss of labor and quality of life during attacks. Results: The mean age of the participants was 44.1±15.00. According to the ID-Migraine Screening test the prevalence of migraine was 15% (n=141) with a rate of 4.7% (n=44) in males and 10.3% (n=97) in females. Based on multivariate analysis the risk of developing migraine is 2.7 times increased by being female (95% CI: 1.75-4.00), and 2.0 times increased by being employed (95 CI: 1.37-3.05). There were 89 women (65.0%) and 40 men (29.2%) who reported migraine attacks affecting daily work. There was no statistically significant relationship between migraine attacks affecting daily life and gender. Conclusion: the prevalence of migraine in western Anatolia was 15%, lower than the average for Turkey. In addition the variables of being female and employed increased the possibility of migraine.
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Tue, 31 Mar 2015 08:42:51 GMT -08:00 http://www.scopemed.org/?mno=169793
Brucellosis in an Adult who was Admitted with Clinical Signs of Orchitis http://www.scopemed.org/?mno=175956 2015-03-31T16-51-00Z
Source: Turkish Journal of Family Medicine & Primary Care
Süheyl Asma, Çiğdem Gereklioğlu, Aslı Korur, Soner Solmaz, Yusuf Ziya Demiroğlu.
Brucellosis is a common infectious disease in developing countries and it usually has systemic symptoms. It is an endemic disease also in our country. It may rarely involve urogenital system. Epidydimo-orchitis may be seen in the course of the systemic disease or may arise as an individual clinical manifestation. Severe testicular complications may develop in case of delay in diagnosis. In this case report, we presented a patient who was diagnosed with brucella orchitis in family medicine outpatient clinc and whose family members were detected to have brucella infection thereafter.
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Tue, 31 Mar 2015 08:42:51 GMT -08:00 http://www.scopemed.org/?mno=175956
Migration of the median nerve to the posterior compartment in a child with supracondylar humeral fracture: a case report http://www.scopemed.org/?mno=152649 2015-03-31T16-51-00Z
Source: Journal of Marmara University Institute of Health Sciences
Sermet İnal, Canan İnal, Ferruh Taşpınar.
The most commonly injured nerve during the supracondylar fractures in children is controversially reported as the median nerve (%28-60), followed by radial and ulnar nerves. The median nerve injury is usually seen in the fractures with posterolaterally displacement and the anterior interosseous branch (AIN) of this nerve is often injured. Here, we present a supracondylar humeral fracture of a 7 years old male child who had a neuropraxia postoperatively, which probably developed intraoperatively during the reposition of the median nerve which was migrated from anterior compartment to the posterior. Although the cause of the nerve stretching is reported to be fracture displacement in the literature, there is no report on stretching of median nerve by migrating to the posterior compartment. Neuropraxia of the AIN can occur in the situations where the median nerve is found to migrate from anterior to posterior compartment in the supracondylar humeral fractures of children. We believe that during the posterior surgical approach for the treatment of the supracondylar fractures of the humerus in children, the tissues over the periosteum must be bluntly dissected to avoid from an iatrogenic median nerve cut.
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Tue, 31 Mar 2015 07:43:37 GMT -08:00 http://www.scopemed.org/?mno=152649
Level of critical thinking and problem solving skills of administrator nurses and nurses who work at private hospitals http://www.scopemed.org/?mno=155047 2015-03-31T16-51-00Z
Source: Journal of Marmara University Institute of Health Sciences
Birsen Erkuş, Nefise Bahçecik.
Purpose: The descriptive study was conducted during September-October 2010 in order to determine critical thinking level and problem solving ability of nurse managers and nurses working at private hospitals. Method: The sample group is formed by 109 nurse managers and 1314 nurses who were available and agreed to take part in the study. Information form including identifying and professional characteristics of nurse managers and nurses, California Critical Thinking Disposition Inventory (CCTDI), and Problem-Solving Inventory (PSI) were used as data collection tools. The data were evaluated with percentage, mean, standard deviation, independent samples test, One-Way ANOVA, Scheffe’s test, and Pearson’s correlation test. Results: CCTDI mean scores were low for the nurse managers (225.2±20.9) and for nurses (222.8±21.4). Mean scores of “systematicity” sub-scale (27.2±3.9) and “inquisitiveness” sub-scale (42.1±6.1) of CCTDI were observed to be higher in nurses compared to nurse managers. PSI mean scores were determined to be average for nurse managers (102.6±12.8) and nurses (101.1±15.6). Mean scores of “problem-solving confidence” (31.4±6.7) and “approach-avoidance” sub-scales (44.5±7.2) of PSI were higher in nurse managers compared to nurses. Age group, educational status, professional working period, unit worked and working type of nurses affected their CCTDI scores whereas educational status of nurse managers and nurses affected PSI scores with statistical significance (p
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Tue, 31 Mar 2015 07:43:37 GMT -08:00 http://www.scopemed.org/?mno=155047
Dendrimers-drug delivery systems http://www.scopemed.org/?mno=164070 2015-03-31T16-51-00Z
Source: Journal of Marmara University Institute of Health Sciences
Büşra Karabulut, Oya Kerimoğlu, Timuçin Uğurlu.
Dendrimers consisting a core, branching units around the core and surface groups also named as functional group are new polymeric drug delivery systems. The variety of dendrimers are provided with functional groups. Branching units of the dendrimer provide its growth iteratively. The space in the interior of the dendrimers allows encapsulation of the active ingredient possible. In this way, the controlled release of the active ingredient can be achieved. However, being in a very branched structure and having many functional groups on the surface provide the addition of variety of molecules and active ingredient by conjugation simultaneously. Thus, targeting of active ingredients to a specific site of the body can be achieved as well as the solubility and bioavailability of the active ingredients can be increased. In this paper, the properties of dendrimers and application areas were evaluated.
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Tue, 31 Mar 2015 07:43:37 GMT -08:00 http://www.scopemed.org/?mno=164070
Studies on hydrazide–hydrazones derivatives as acetylcholinesterase inhibitors http://www.scopemed.org/?mno=158141 2015-03-31T16-51-00Z
Source: Journal of Marmara University Institute of Health Sciences
Usama Abu Mohsen, Bedia Koçyiğit-Kaymakçıoğlu, Emine Elçin Oruç-Emre, Zafer Asım Kaplancıklı, Sevim Rollas.
Objective: Fifteen hidrazide-hydrazone derivatives were synthesized and evaluated for their ability to inhibit acetylcholinesterase (AChE) using a modification of Ellman’s spectrophotometric method. Methods: Anti-acetylcholinesterase activity was evaluated by using a modification of Ellman’sspectrophotometric method. The spectrophotometric method is based on the reaction of released thiocholine to give a coloured product with a chromogenic reagent 5,5-dithio-bis-(2-nitrobenzoic acid). Results: Among the tested compounds, 4-fluorobenzoic acid [(4-methoxyphenyl) methylene] hydrazide (6) and 2-[(fluorobenzoyl) hydrazono]-1,3-dihydro-indol-3-one (15), showed noteworthy anti-AChE activity when compared to standard drug donepezil (IC50=0.054±0.002µM). Conclusion: The anti-AChE activity screening indicated that among the tested compounds, 6 with p-methoxyphenyl substitution and 15 with1,3-dihydro-indol-3-one substitution represent the most active compounds. Based on the activity results, it appears that bulky groups on the hydrazide-hydrazone moiety have made good contribution to the anti-AChE activity.
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Tue, 31 Mar 2015 07:43:37 GMT -08:00 http://www.scopemed.org/?mno=158141
Gingival changes in a drug-induced gingival overgrowth patient using tacrolimus: a case report http://www.scopemed.org/?mno=164010 2015-03-31T16-51-00Z
Source: Journal of Marmara University Institute of Health Sciences
Neslihan Nal Acar, Leyla Kuru, Ulku Noyan.
This case report presents a 33 year-old female renal transplant recipient who presented to our clinic with her chief complaint of gingival overgrowth. Following clinical and radiographic examinations, she was diagnosed with chronic periodontitis accompanied by cyclosporin A and nifedipine-induced gingival overgrowth. Initial periodontal therapy and replacement of cyclosporin A with tacrolimus, with continued nifedipine usage, were performed. Marked improvements in clinical parameters were observed within 3 months. Bilateral ulcerated lesions which were observed on attached gingiva of the upper and lower premolar regions 2 months after commencement of tacrolimus usage, were histopathologically examined and diagnosed with nonspecific ulcerations. These lesions disappeared within 2 months after the dose of tacrolimus was decreased. In this case report, a renal transplant patient with chronic periodontitis and gingival overgrowth was treated with scaling/root planning and conversion from cyclosporin A to tacrolimus. Ulcerations on the gingiva were assumed to have resulted from tacrolimus usage.
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Tue, 31 Mar 2015 07:43:37 GMT -08:00 http://www.scopemed.org/?mno=164010
Probiotics in periodontal therapy http://www.scopemed.org/?mno=166596 2015-03-31T16-51-00Z
Source: Journal of Marmara University Institute of Health Sciences
Hafize Öztürk Özener, Bahar Eren Kuru.
Probiotics, defined as live microorganisms which are beneficial for health, are being used in the treatment of gastrointestinal disorders with success for many years. In recent years, researchers have sparked interest in the efficiency of the probiotics in periodontal health and treatment, based on their effects to support the immune system and suppress pathogenic microorganisms. The role and activity of probiotics in periodontal therapy are evaluated in this review. Probiotic research in periodontology is still in its start up phase. Nevertheless, pioneering results in periodontal health and periodontal therapy are encouraging, and with these data, a certain basis for the generation of further exhaustive and long-term studies are warranted.
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Tue, 31 Mar 2015 07:43:37 GMT -08:00 http://www.scopemed.org/?mno=166596
A new approach in cancer treatment: poly (ADP-ribose) polymerase-1 inhibitors http://www.scopemed.org/?mno=166598 2015-03-31T16-51-00Z
Source: Journal of Marmara University Institute of Health Sciences
Fatih Tok, Bedia Koçyiğit-Kaymakçıoğlu.
Internal and external factors can damage DNA, the genetic material. Numerous repair mechanisms, which can repair those damages, exist in the normal cell. One of those is called PARP-1 enzyme. PARP-1 transfers ADP-ribose subunits from nicotinamide adenine nucleotide to protein acceptor. Thus, single strand DNA breaks can be repaired. If PARP-1 inhibition occurs, single strand DNA breaks cannot be repaired and double strand DNA breaks can be formed. Eventually, cells undergo necrosis or apoptosis. The aim of cancer treatment is to inhibit the PARP-1 enzyme. For this purpose, many studies have been published over the last decade and currently PARP-1 enzyme inhibitors which are in the phase studies and which are waiting to be marketed are available. In this review, information are given for the mechanisms by which DNA damage is repaired, the protection mechanism of the genomic integrity of PARP enzyme family and chemical structure of PARP-1 inhibitors which are improved to use in cancer treatment.
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Tue, 31 Mar 2015 07:43:37 GMT -08:00 http://www.scopemed.org/?mno=166598
Relationship between initial probing depth and residual pockets following mechanical periodontal treatment http://www.scopemed.org/?mno=168109 2015-03-31T16-51-00Z
Source: Journal of Marmara University Institute of Health Sciences
Süleyman Emre Meşeli, Bahar Kuru, Leyla Kuru.
Objective: The aim of this study was to evaluate the relationship between initial probing depth (IPD) and the ratio of residual periodontal pocket in chronic periodontitis patients following mechanical periodontal therapy (MPT). Methods: A total of 1102 periodontal pockets with IPD 4-9 mm (both included) in 11 chronic periodontitis (CP) patients were included and grouped according to their IPDs and number of roots (single-/multi-rooted). MPT consisting of oral hygiene instruction, scaling and root planing was applied in 2 sessions with one-week interval. Plaque index, gingival index, probing depth (PD), clinical attachment levels and bleeding on probing (BoP) were measured before and 8 weeks after MPT. Following MPT, periodontal pockets demonstrating PD?5 mm and BoP (+) were defined as residual periodontal pockets. Results: Our results showed that 10.89% of the sites from single-rooted teeth and 26.59% of the sites from multi-rooted teeth were remained as residual periodontal pockets. Further, positive correlations were found between IPD and residual periodontal pocket ratio for both single- and multi-rooted teeth (p
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Tue, 31 Mar 2015 07:43:37 GMT -08:00 http://www.scopemed.org/?mno=168109
Role of the cholinergic anti-inflammatory pathway in endotoxemia-induced multi-organ damage in the rat http://www.scopemed.org/?mno=742 2015-03-31T16-51-00Z
Source: Journal of Marmara University Institute of Health Sciences
Meltem Kolgazi, Fatih Özgür, Ömer Beyazoğlu, Ali Kocagöz, Mehmethan Çelik, Merve Açıkel Elmas, Meral Yüksel, Feriha Ercan, İnci Alican.
Objective: To investigate the role of the cholinergic anti-inflammatory pathway and interaction of inducible nitric oxide (iNOS) and cycloxygenase (COX)-2 in organ dysfunction in rat sepsis. Methods: Lipopolysaccharide (LPS) (10 mg/kg; intraperitoneally) was given to Sprague-Dawley rats to induce sepsis. Groups were treated with nicotine alone or with nicotinic receptor antagonist mecamylamine (3 mg/kg; subcutaneously), selective iNOS inhibitor aminoguanidine (8 mg/kg; intraperitoneally) or selective COX-2 inhibitor nimesulide (8 mg/kg; intraperitoneally). Six hours after LPS, liver, kidney and lung samples were obtained for malondialdehyde (MDA), glutathione (GSH), myeloperoxidase (MPO), chemiluminescence assays and microscopic evaluation and blood was obtained for alanine transaminase (ALT), aspartate aminotransferase (AST) and blood urea nitrogen (BUN) assays. Results: Sepsis increased ALT (p
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Tue, 31 Mar 2015 07:43:37 GMT -08:00 http://www.scopemed.org/?mno=742
Biomarkers in cardiovascular surgery biomarkers as early predictors for organ damage after cardiac surgery http://www.scopemed.org/?mno=172332 2015-03-31T16-51-00Z
Source: Journal of Marmara University Institute of Health Sciences
Tijen Alkan Bozkaya.
A biomarker is a measureable substance produced by the body and used to diagnose or determine the biologic state. Most biomarkers used in the clinical medicine are the genes, proteins or other chemical substances that are expressed in the pathology or organ damage, allowing for early and fast diagnosis and treatment. Ideally, biomarkers must be generally highly sensitive in order to make an early diagnosis; provide certain cut-off values to enable risk assessment, therapeutic guidance and have prognostic value. Cardiopulmonary bypass (CPB) is a model of extracorporeal circulation consisting primarily of a pump, a reservoir and an oxygenerator. At the initiation of CPB, blood is drained from the patient into the extracorporeal circuit which has non-endothelial surface. The inflammatory process occurs after cardiac surgery in varied degrees depending on the genotypes and peroperative parameters or complexity of the cardiac pathology. This process is mediated by cellular, noncellular or humoral components of the blood. Today, safe clinical biomarkers are detected by gene technology and proteomics techniques. Using these innovative technologies, the discovery, validation and clinical use of several biomarkers have revolutionized the diagnosis and management in the field of cardiovascular surgery as well as other major medical disciplines.
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Tue, 31 Mar 2015 07:43:37 GMT -08:00 http://www.scopemed.org/?mno=172332
Foetometrics and Economic Impact Analysis of Reproductive Wastages in Ruminant Species Slaughtered in North-Eastern Nigeria http://www.scopemed.org/?mno=149992 2015-03-31T16-51-00Z
Source: Journal of Animal Production Advances
Gideon Dauda Mshelia, Victoria Adams Maina, Musa Dahiru Aminu.
A study was conducted to assess the foetometric characteristics and reproductive wastages in ruminant livestock slaughtered in Maiduguri. The volume of animals slaughtered and the corresponding rates of pregnancy wastages were recorded. The gestational stages of the foetuses wasted were determined by the measures of their respective Crown Rump Length (CRL) and Weights (W). There were 420 and 28 pregnant does and cows slaughtered respectively. The CRL and weights of both caprine and bovine foetuses recovered were 7 to 37 cm and 1 to 4 Kg; and 10 to 83 cm and 2 to 10 kg respectively. The rate of pregnancy wastage was higher (21%) among the does than the cows (15%) with the highest (p0.05). The economic cost of the total foetal wastages in the present study was estimated at US$ 559,440 annually, suggesting that the impact of such wastages could be worrisome nationwide. It is therefore critical that remedial measures should be put in place to forestall the occurrence of this ugly situation in the Nigerian livestock economy.
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Tue, 31 Mar 2015 07:17:12 GMT -08:00 http://www.scopemed.org/?mno=149992
Endogenous vasoactive mediators in defense of portal hypertensive gastric mucosa http://www.scopemed.org/?mno=165896 2015-03-31T16-51-00Z
Source: Journal of Experimental and Integrative Medicine
Paula Rubya Souza Camara.
The inflammatory mediators can alter the integrity of mucosa by effectively influencing the various components of the mucosal defense, which are a combination of factors that allow the mucosa withstand exposure to substances with different types of pH range, temperature and osmosis, solutions with detergent properties (bile) and bacterial products that can activate local and systemic inflammatory reactions. On the other hand, our previous research showed that different kinds of intragastric pH range can to protect or induce gastric damage in portal hypertensive rats. When damage occurs to the mucous membrane, repair of the lesion can be activated quickly, limiting the possibility of harmful substances (bacterial products) coming into contact with the systemic circulation. The resistance of the gastric mucosa to injury depends, ultimately, on a balance between defensive factors and aggressive factors present in the lumen of the mucosa. Various components of mucosal defense can be influenced by inflammatory mediators. Some of these mediators are prostanoids, nitric oxide, endothelins, cytokines, free radicals, neuropeptides and Helicobacter pylori. These mediators contribute to both the modulation of mucosal defense and the pathogenesis of gastric mucosal injury, and will be described a little more detail in the present paper.
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Tue, 31 Mar 2015 05:58:39 GMT -08:00 http://www.scopemed.org/?mno=165896
Starting the fifth year of publication: switching from road to highway http://www.scopemed.org/?mno=183554 2015-03-31T16-51-00Z
Source: Journal of Experimental and Integrative Medicine
Sukru Oter, Kemal Simsek.

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Tue, 31 Mar 2015 05:56:39 GMT -08:00 http://www.scopemed.org/?mno=183554
CLINICAL MANAGEMENT OF PREPARTUM RECURRENT RECTO-VAGINAL PROLAPSE IN A COW http://www.scopemed.org/?mno=182352 2015-03-31T16-51-00Z
Source: International Journal of Livestock Research
Saraswat Sahoo, Bijay Kumar Patra, Debendra Narayan Mohanty.
A clinical case of recurrent prepartum recto-vaginal prolapse in a cow along with its ther-apeutic measures is discussed.
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Tue, 31 Mar 2015 04:51:49 GMT -08:00 http://www.scopemed.org/?mno=182352
Acute primary Psoas abscess in a Hepatitis B positive child presenting as hip Pathology- A rare case report http://www.scopemed.org/?mno=183716 2015-03-31T16-51-00Z
Source: The Southeast Asian Journal of Case Report and Review
Ganesh Singh Dharmshaktu, Irfan Khan,Shailendra Singh Bhandari.
Hip pain and related complaints have many differentials but psoas abscess as cause of it is not common phenomenon. Furthermore, such settings can further delay the diagnosis by diversion. Good clinical acumen and appropriate use of modern imaging modalities is instrumental to diagnose it early for better management. The presented case highlights importance of looking ‘beyond hips’ and ascertain the diagnosis in doubtful cases with advance imaging techniques. The case is unreported account of primary psoas abscess presenting acutely as a hip case in a hepatitis B positive child. Early drainage of pus is cornerstone of prompt recovery with good predicted outcome.
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Tue, 31 Mar 2015 04:37:11 GMT -08:00 http://www.scopemed.org/?mno=183716
Acute primary Psoas abscess in a Hepatitis B positive child presenting as hip Pathology- A rare case report http://www.scopemed.org/?mno=183715 2015-03-31T16-51-00Z
Source: The Southeast Asian Journal of Case Report and Review
Ganesh Singh Dharmshaktu, Irfan Khan, Shailendra Singh Bhandari.
Hip pain and related complaints have many differentials but psoas abscess as cause of it is not common phenomenon. Furthermore, such settings can further delay the diagnosis by diversion. Good clinical acumen and appropriate use of modern imaging modalities is instrumental to diagnose it early for better management. The presented case highlights importance of looking ‘beyond hips’ and ascertain the diagnosis in doubtful cases with advance imaging techniques. The case is unreported account of primary psoas abscess presenting acutely as a hip case in a hepatitis B positive child. Early drainage of pus is cornerstone of prompt recovery with good predicted outcome.
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Tue, 31 Mar 2015 04:31:01 GMT -08:00 http://www.scopemed.org/?mno=183715
A Case of Prolonged Neck Pain Diagnosed with Grisel’s syndrome as a Differential Diagnosed with Juvenile Idiopathic Arthritis http://www.scopemed.org/?mno=157979 2015-03-31T16-51-00Z
Source: Annals of Paediatric Rheumatology
Gonca Keskindemirci, Nuray Aktay Ayaz, Şeyma Mürtezaoğlu, Ali Er, İbrahim Alataş, Gönül Aydoğan.
Grisel’s syndrome is an important cause of torticollis. The syndrome is a non-traumatic atlantoaxial subluxation that follows upper respiratory infection disease, surgery or romatologic disease. Subluxation occurs as a result of inflamed transverse and alar ligament, which stabilizes atlantoaxial joint. This case report focuses on the diagnosis of Grisel’s syndrome of a six –years old girl patient. She was consulted to pediatric rheumatology for having painfull toticollis for two months. It is found that the symptom started after having respiratory infection disease. She was diagnosed of Grisel’s syndrome following radiologic examination. She responded to conservative treatment, that included bed rest, external fixation, antibiotic therapy, muscle relaxants, and anti-inflammatory therapy. The case is reported to point out that one of the ethiology of painfull tortocollis through making differantial diagnoses of juvenile rheumatoid arthritis, that is itself diagnosed with radiologic examination should be considered.
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Tue, 31 Mar 2015 02:13:48 GMT -08:00 http://www.scopemed.org/?mno=157979
Erlenmeyer Flask Bone Deformity in a Child with Polyarthritis: Could This be a Distinct Disorder? http://www.scopemed.org/?mno=1031 2015-03-31T16-51-00Z
Source: Annals of Paediatric Rheumatology
Intisar Albuhairan, Khalid Alismail, Zahra AlSahlawi, Mohammed AlOwain, Sulaiman M Al-Mayouf.
We describe a girl with juvenile idiopathic arthritis found to have Erlenmeyer flask bone deformity. This case serves to remind physicians to look for unusual findings in children with JIA and discuss the likelihood of association between Erlenmeyer flask bone deformity and juvenile idiopathic arthritis.
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Tue, 31 Mar 2015 02:13:48 GMT -08:00 http://www.scopemed.org/?mno=1031
New Insights to the Pathogenesis of two Orphan Vasculitides: Childhood Polyarteritis Nodosa and Behçet Disease http://www.scopemed.org/?mno=174528 2015-03-31T16-51-00Z
Source: Annals of Paediatric Rheumatology
Ekim Z. Taskiran, Ezgi Deniz Batu, Levent Kilic, Ali Akdogan, Engin Yilmaz, Seza Ozen.
Vasculitides are heterogeneous group of disorders that feature inflammation of the blood vessels. The aim of this study was to investigate the role of TNF-α, MMP9 and the balance between Th17 and Tregs in two ANCA negative vasculitides, polyarteritis nodosa (PAN) and Behçet disease. Peripheral blood lymphocytes were isolated from 3 patients with childhood PAN, 4 with Behçet disease and three controls. mRNA levels of FoxP3, IL-17, TNF-α and MMP9 were studied by qRT-PCR and analyzed as described previously. IL-17, MMP9, TNF-α expressions were significantly increased compared to normal controls (p=0.0322, p=0.0011, and p=0.0235 respectively) in both diseases. There was no difference in the expression for FoxP3. Our results suggest that Th17 cells participate in the inflammation of PAN and Behçet disease. Increased expressions of TNF-α and MMP9 suggest their role in the pathogenesis as well.
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Tue, 31 Mar 2015 02:13:48 GMT -08:00 http://www.scopemed.org/?mno=174528
Sapho (Synovitis, Acne, Pustulosis, Hiperosteosis and Osteitis) Syndrome: A Case Report and Review of Literature http://www.scopemed.org/?mno=176922 2015-03-31T16-51-00Z
Source: Annals of Paediatric Rheumatology
Serkan Turkucar, Betul Sozeri, Aysenur Pac Kisaarslan, Emel Unsur, Hakan Poyrazoglu, Zubeyde Gunduz, Ruhan Dusunsel.
SAPHO is a syndrome that Synovitis, Acne, Pustulosis, Hiperosteosis and Osteitis seen with. Synovitis of anterior chest wall joints, severe acneiform lesions and osteitis are disease specific findings. In our case, 16 years old a typical SAPHO syndrome patient, whose acromioclavicular and sternoclavicular joints involvement were proven via MR imaging and the evaluation of scintigraphy, was presented.
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Tue, 31 Mar 2015 02:13:48 GMT -08:00 http://www.scopemed.org/?mno=176922
A Novel Mutation in the Gene Encoding Tumor Necrosis Factor Receptor Super Family: Dilemmas of Outcome Predictability http://www.scopemed.org/?mno=180291 2015-03-31T16-51-00Z
Source: Annals of Paediatric Rheumatology
Anjali Patwardhan, Kate July.
TRAPS are most common autosomal dominantly inherited periodic fever syndrome with autosomal dominant inheritance. It is an autoinflammatory condition resulting from mutation in tumor necrosis factor receptor super family 1A gene (TNFRSF1A). TNF receptor protein plays a key role in inflammation. Clinical features involve high grade fever and systemic inflammation of various organs and systems. The most dreaded complication of TRAPS is amyloidosis and end organ failure. Specific mutations and poorly controlled inflammation increase the risk for amyloidosis. Currently 141 sequence variants of TNFRSF1A gene are known. We report a novel mutation of TNFRSF1A gene variant I199T in a nine-year-old Caucasian female with clinical and laboratory features of tumor necrosis factor receptor associated periodic syndrome (TRAPS). She had no significant family history and who responded well to steroids and Interleukin-1 receptor antagonist (IL-1Ra) therapy. To our knowledge I199T variant has not been reported or published so far. Limited understanding of the functional status of sequence variants makes it impossible to predict disease association & pathogenicity in de novo mutations especially as they occur in non-familial settings. Asymptomatic parents should be tested to confirm if the mutation is de novo in which case it is likely to be pathogenic and patient will require vigorous treatment to avoid amyloidosis. It is important to treat the patient with this mutation to avoid long term damages especially amyloidosis.
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Tue, 31 Mar 2015 02:13:48 GMT -08:00 http://www.scopemed.org/?mno=180291
Is Interferon-Induced Psychotic Depression Associated with Extra-Pyramidal Sensitivity? http://www.scopemed.org/?mno=48112 2015-03-31T16-51-00Z
Source: Bulletin of Clinical Psychopharmacology
İbrahim Taymur, Serap Sarı, Bülent Belkiz Güngör, Ahmet İnel, Özgur Dağlı, Rustem Aşkın, Ayşe Nur Burcu.
During treatment with interferon psychiatric syndromes like depression is frequently observed. 17 years old male patient had increasing depressive symptoms in 8th week of interferon treatment which led to psychotic depression. Interferon treatment was discontinued and antipsychotic drugs were given which resulted in extrapyramidal side effects. Low dose atypic antipsychotics which led to extrapyramidal side effects in psychotic depression due to interferon treatment were reported in some cases before. In literature there is no enough knowledge about use of antipsychotics in treatment of these patients. Our case showed that cases with psychotic symptoms after interferon treatment can have extrapyramidal sensitivity
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Tue, 31 Mar 2015 01:36:33 GMT -08:00 http://www.scopemed.org/?mno=48112
The Clinical Relevance of Information Sources on Drug-Drug Interaction http://www.scopemed.org/?mno=173492 2015-03-31T16-51-00Z
Source: Bulletin of Clinical Psychopharmacology
Yusuf Cem Kaplan.

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Tue, 31 Mar 2015 01:36:33 GMT -08:00 http://www.scopemed.org/?mno=173492
The associations between endogenous oxytocin levels and emotion recognition in bipolar disorder http://www.scopemed.org/?mno=42919 2015-03-31T16-51-00Z
Source: Bulletin of Clinical Psychopharmacology
Cumhur Taş, Elliot C. Brown Ece Onur, Ömer Aydemir, Martin Brune.
Objective: Recent studies in patients with Bipolar Disorder (BD) have revealed problems in emotion recognition, specifically for negative emotions, which have been subsequently related to amygdala activity. Previously, the prosocial neuropeptide oxytocin has been shown to be one hormone that alters emotion perception capacities and modulates amygdala response. Accordingly, the aim of this study was to see if plasma oxytocin levels have specific effects on predicting emotion recognition patterns in BD. Methods: Twenty-eight remitted BD patients were recruited for this study and the Vienna Emotion Recognition Task was given. In addition, blood samples were collected for plasma oxytocin analysis. Results: Strong associations were found between fearful emotions and basal oxytocin levels, which were supported by a stepwise regression analysis. Patients with higher levels of basal oxytocin also exhibited greater recognition of fearful emotions. Conclusions: The relationship between recognition of fearful faces and individual endogenous oxytocin levels may contribute to explaining individual differences in social functioning and amygdala dysfunction in BD.
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Tue, 31 Mar 2015 01:36:33 GMT -08:00 http://www.scopemed.org/?mno=42919
The evaluation of mental status of elderly patients presenting to emergency services and the comparison between the last diagnosis and their complaints http://www.scopemed.org/?mno=48280 2015-03-31T16-51-00Z
Source: Bulletin of Clinical Psychopharmacology
Umit Kaldırım, Murat Eroğlu, Murat Durusu, Ali Osman Yıldırım, Salim Kemal Tuncer, Yusuf Emrah Eyi, İbrahim Arziman, Cengiz Kaya, Cengizhan Acıkel, Levent Yamanel.
Introduction: The number of geriatric patients presenting to the emergency department increases every year. In addition, it is known that the mental status of geriatric patients may deteriorate as they age. In the emergency department, one of the main premises of patient management is anamnesis. However, impairments in mental status of geriatric patients decrease the reliability of anamnesis. In this study, we aimed to determine the mental status of elderly patients who presented to the emergency department, the relationship between mental status and patients’ complaints, and last diagnoses and mortality. Materials and Methods: The study was planned to be prospective. The mental status of geriatric patients who presented to the emergency department was evaluated with a six-question screening test. Complaints, final diagnosis information, hospitalization department, duration of hospitalization, judicial status and mortality information were recorded. Consistency between patients’ complaints and symptoms determined in physician examination was evaluated. Symptom-finding consistency levels based on mental status were compared. Kappa tests for consistency assessments and chi-square test for intergroup comparisons were used. Findings: The match between patient complaints and final diagnosis of 755 patients was evaluated by two independent specialist physicians. As a result of the six-question screening test, a mismatch between patient complaint and final diagnosis was found in 16.2% of 204 patients with abnormal screening tests (n=33) compared to 0.4% of 551 patients, who had a normal screening test (n=2). Mortality was found to be 9.8% in patients with abnormal test results while it was found to be 2.0% in patients with normal screening tests. Conclusion: Mental status variance determined in elderly patients appears to be a risk factor in terms of mortality. Complaints in geriatric patients having mental status variance can be deceptive in terms of pointing to the current disease. Exploring this relationship in detail with further studies should be considered, in order to make a significant contribution to the service provided to this patient group.
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Tue, 31 Mar 2015 01:36:33 GMT -08:00 http://www.scopemed.org/?mno=48280
The role and efficacy of clozapine treatment in early-onset and very early-onset schizophrenia cases: discussion of five cases http://www.scopemed.org/?mno=151478 2015-03-31T16-51-00Z
Source: Bulletin of Clinical Psychopharmacology
İpek Percinel, Kemal Utku Yazıcı, Hatice Serpil Erermiş, Burcu Özbaran, Sezen Gökçen Köse, Joanna Zemla, Tuğba Donuk, Bülent İdris.
Schizophrenia is a serious mental disorder emerging at an early age, characterized by significant breakdowns in thought, perception and behavioral processes and withdrawal from human relationships. Psychopharmacologic and psychosocial approaches should be combined for the treatment of schizophrenia. Although the effects and side effects of both typical and atypical antipsychotics have been studied in adult patients in detail, studies in child and adolescent age groups are inadequate. Clozapine is a prototype of atypical antipsychotics and the first antipsychotic to be defined as atypical. Clozapine is often effective in cases in which typical and other atypical antipsychotics fail, and is accepted as the “gold standard” in the treatment of schizophrenia. In this paper, the effects and side effects of clozapine in five adolescent cases diagnosed with schizophrenia are discussed. Four of these cases showed that clozapine is effective in adolescent schizophrenia. While the four cases showing good responses to the treatment tolerated clozapine well, the other case (case 4) showed an apparent decreasing trend in neutrophil count a short while after starting the treatment and his medication was stopped at the request of his parents.
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Tue, 31 Mar 2015 01:36:33 GMT -08:00 http://www.scopemed.org/?mno=151478
Panic disorder induced by a “herbal” product containing sibutramine: case series with review of literature http://www.scopemed.org/?mno=151943 2015-03-31T16-51-00Z
Source: Bulletin of Clinical Psychopharmacology
Defne Eraslan, Aylin Aksoy Çoban, Erhan Ertekin.
Sibutramine is a serotonin and noradrenaline reuptake inhibitor which has been used for weight loss in obese patients. There are slimming products on the market claiming to be ‘natural’ which nevertheless contain sibutramine. In this report, we present three cases where panic attacks were associated with the use of a product and persisted even long after its discontinuation.
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Tue, 31 Mar 2015 01:36:33 GMT -08:00 http://www.scopemed.org/?mno=151943
Age associated sleep loss: a trigger for Alzheimer’s disease http://www.scopemed.org/?mno=157795 2015-03-31T16-51-00Z
Source: Bulletin of Clinical Psychopharmacology
Vivek Kumar Sharma, Preety Sharma, Rahul Deshmukh, Ranjit Singh.
Alzheimer’s disease (AD) is an untreatable, multifactorial, chronic, progressive, neurodegenerative disorder, which is the principal cause of dementia throughout the world and the fourth most important cause of death in developed economies after cancer, cardiovascular diseases, and vascular stroke. The so-called Alzheimer’s epidemic inevitably represents a major health problem to most nations, because there is no effective cure or preventive measure. Present cholinergic and glutamatergic drugs for the treatment of AD are largely symptomatic with temporary clinical benefits regarding cognitive, functional and behavioral manifestations of the disease but with no effect on its progression. Thus, there is a crucial need to discover new and efficient therapeutic strategies. Targeting behavioral aspects of AD represents an approach that may bear fruit, taking a cue from the success of cholinergic treatments in AD. Loss of sleep is a common problem associated with aging and with AD in particular. Clinical evidence has showed that people who suffer from chronic insomnia are about 11 times more likely to develop Alzheimer’s disease in later life. Sleep, a behavioral state exhibited by nearly all species, is common in the animal kingdom and has been well preserved in the course of evolution. Sleep is widely considered to be instrumental in maintaining health and cognitive functions. It is a major modulator of several developmental processes including hormone release, glucose regulation, cardiovascular functions, neurogenesis, immune functions, and physiologic balance and resilience. Reduced sleep duration and quality appears to be endemic in modern society; it is a stressor affecting the brain in many ways, including loss of memory and cognitive functions. Alzheimer’s disease is typically accompanied by daytime sleepiness and napping as well as severe disruption of nighttime sleep patterns; indeed, disruption of nighttime sleep is often cited as the primary reason for institutionalization of patients. In this review, recent and updated evidence linking sleep disruption to pathological factors playing a decisive role in the progression of Alzheimer’s disease is discussed.
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Tue, 31 Mar 2015 01:36:33 GMT -08:00 http://www.scopemed.org/?mno=157795
Association of HTR2A polymorphisms with risperidone efficacy in Chinese Han schizophrenia patients http://www.scopemed.org/?mno=158638 2015-03-31T16-51-00Z
Source: Bulletin of Clinical Psychopharmacology
Yucai Yan, Zhiyun Wei, Yuyu Xiong, Jie Jiang, Ran Huo, Lu Shen, Liya Sun, Yichen Liu, Donghong Cui, Wenqiang Li, Jingyuan Zhao, Lin He, Qinghe Xing, Shengying Qin.
Objectives: The 5-HT2A receptor is one of the most important serotonin receptors, serving as a major target for risperidone. Rs6311 and rs6313 polymorphisms in the HTR2A gene have been reported to be associated with response to risperidone treatment; however, many previous studies have yielded conflicting results. To confirm the importance of these polymorphisms in risperidone treatment and provide more evidence for the routine use of these pharmacogenetic biomarkers in clinical practice, we carried out an association analysis of rs6311 and rs6313 polymorphisms with risperidone efficacy in Chinese Han patients with schizophrenia. Methods: Two independent cohorts of unrelated subjects were recruited from Henan and Shanghai (95 and 113 subjects, respectively). After 4- or 8-week risperidone monotherapy, the rs6311 and rs6313 polymorphisms of these subjects were genotyped with direct DNA sequencing. Clinical improvement was measured by the reduction of the PANSS scores (including the total and subscale scores). UNIANOVA and case-control study was used to evaluate the effects of rs6311 and rs6313 polymorphisms on the therapeutic efficacy of risperidone. Results: As in previous studies, the rs6311G allele was found in complete linkage disequilibrium with the rs6313C allele. However, neither the rs6311 nor the rs6313 polymorphism significantly influenced clinical improvement during risperidone treatment. Neither the allele nor the genotype frequencies were significantly different between responder and non-responder subgroups. Conclusions: No significant association between HTR2A polymorphisms (rs6313 and rs6311) and risperidone efficacy was found in the present study. The relative large sample size and two independent cohorts of subjects in the present study enhance the reliability of our findings.
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Tue, 31 Mar 2015 01:36:33 GMT -08:00 http://www.scopemed.org/?mno=158638
A comparative study on olanzapine and aripiprazole for symptom management in female patients with borderline personality disorder http://www.scopemed.org/?mno=162169 2015-03-31T16-51-00Z
Source: Bulletin of Clinical Psychopharmacology
Saeed Shoja Shafti, Hamid Kaviani.
Objective: While Second Generation Antipsychotics (SGAs) have been shown, in some studies, to be helpful for amelioration of impulsiveness, aggressiveness and moodiness of patients with Borderline Personality Disorder (BPD), there are additional studies that believe that the evidence does not currently support effectiveness of SGAs for overall severity of borderline symptoms. In light of these conflicting reports, we conducted a trial to compare the efficacy and safety of olanzapine vs. aripiprazole with regard to management of BPD. Method: Twenty-four female inpatients, meeting the diagnosis of BPD according to the DSM-IV-TR criteria, were randomly entered into an 8-week parallel group, open-label study for random assignment to olanzapine or aripiprazole (n=12 in each group). The patients were selected from outpatients among clientele of two psychiatric clinics and also inpatients from female wards of Razi psychiatric hospital. Patients were excluded from the trial if any prominent co-morbid mental disorder was present. The primary outcome measure included the Brief Psychiatric Rating Scale (BPRS) for estimation of baseline psychopathology, clinical outcome and treatment response. In addition, the Buss-Durkee Hostility Inventory (BDHI) for the assessment of anger and hostility, and the Clinical Global Impressions-Severity Scale (CGI-S) for assessment of overall illness severity were used as secondary scales. Changes in mean total scores of the BPRS, CGI-S and BDHI were analyzed within each group by means of a paired t test and compared across the two groups by an unpaired t test. Statistical significance was defined as a 2-sided p value < or = to 0.05. In addition, analysis of effect size (ES) by calculation of Cohen’s d was performed and recorded. Results: All of the patients remained in and completed the study. According to the findings olanzapine and aripiprazole reduced mean total score of the BPRS about 25.7% and 18.8% in their groups, and thus illustrated a significant improvement of primary outcome measure at the end of the trial, in comparison with baseline (p
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Tue, 31 Mar 2015 01:36:33 GMT -08:00 http://www.scopemed.org/?mno=162169
Diagnostic Performance of the Turkish Version of the Vancouver Obsessional Compulsive Inventory (VOCI) versus Padua Inventory-Revised (PI-R): a validation study http://www.scopemed.org/?mno=166752 2015-03-31T16-51-00Z
Source: Bulletin of Clinical Psychopharmacology
Murat Boysan, Mustafa Güleç, Erdem Deveci, Yaşar Barut.
Objective: The Vancouver Obsessional Compulsive Inventory (VOCI) is a self-report inventory developed to assess a wide range of obsessive-compulsive symptoms, including contamination (12 items), checking (6 items), obsessions (12 items), hoarding (7 items), just right (12 items), and indecisiveness (6 items). The English version of the VOCI has been shown to be a promising psychometric instrument, as have its French, Italian, and Spanish versions. The aim of this study was to investigate psychometric properties of the Turkish version of the VOCI in clinical and non-clinical samples. Method: A questionnaire package including the VOCI, Padua Inventory-Revised (PI-R), Obsessional Beliefs Questionnaire (OBQ), and Beck Depression Inventory (BDI) was administered to volunteer undergraduates (n=365) and patients with obsessive-compulsive disorder (OCD) (n=46). Psychometric analyses were run to assess reliability and validity of the Turkish version of the VOCI. We converged a confirmatory factor analysis to test the factor structure. We also performed a receiver operating characteristic (ROC) analysis to determine cut-off scores and compared the diagnostic performance of the VOCI and PI-R. Convergent and discriminant validity of the VOCI were assessed through Pearson product-moment correlation coefficients. Internal consistency and temporal reliability were computed. Results: Confirmatory factor analysis replicated the original six-factor structure. The maximum likelihood factor loading estimates were higher than 0.40. OCD patients scored significantly higher than control subjects on the contamination, checking, obsessions, things just right, and indecisiveness subscales of the VOCI but not on the hoarding subscale. The global VOCI scores highly correlated with the PI-R (r=0.89); correlation between the contamination subscale of the VOCI and washing subscale of the PI-R was r=0.88; correlation between the checking subscales of both screening tools was r=0.83; correlation between the just right subscale of the VOCI and precision subscale of the PI-R was r=0.71; and correlation between the obsession subscale of the VOCI and rumination subscale of the PI-R was r=0.71. Divergent validity of the VOCI was also high, so that correlations of the total and subscales of the VOCI with the total and subscales of the PI-R were from r=0.25 to a high of r=0.41; therefore, it can be said that the coefficients ranged from weak to moderate. These correlation coefficients were indicative of good convergent and divergent validity. Internal consistency of the VOCI global was 0.97, and that of the VOCI subscales ranged between 0.82 and 0.92 in the overall sample. Cronbach’s Alphas of the VOCI subscales in the OCD group were between 0.73 and 0.88, and in the control group between 0.84 and 0.92. Fifteen-day test-retest intra-correlations for total scores of the VOCI were 0.75; for the subscales they ranged from 0.68 up to 0.88. The ROC analysis demonstrated a moderate diagnostic performance for the VOCI cut-off score of 87.5 with a sensitivity of 0.74 and a specificity of 0.73 immediately comparable to the PI-R cut-off point of 67.5. Conclusion: The VOCI had good internal consistency, test-retest reliability, convergent and discriminant validity. It is concluded that the Turkish version of the VOCI has sound psychometric properties. Further studies are needed to develop psychometric tools with stronger diagnostic performance for OCD assessment.
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Tue, 31 Mar 2015 01:36:33 GMT -08:00 http://www.scopemed.org/?mno=166752
Relationship between plasma levels of prolactin and the severity of negative symptoms in patients with schizophrenia http://www.scopemed.org/?mno=167293 2015-03-31T16-51-00Z
Source: Bulletin of Clinical Psychopharmacology
Mehmet Alpay Ateş, Recep Tütüncü, İbrahim Öner, Sarper Ercan, Cengiz Başoğlu, Ayhan Algül, Hakan Balıbey, Osman Metin İpcioğlu, Mesut Çetin, Servet Ebrinç.
Objective: The aim of this study was to evaluate the relationship between plasma levels of prolactin and negative symptoms. Methods: One hundred fourteen patients with schizophrenia were included in this cross-sectional study. The patients were classified into groups with and without hyperprolactinemia. Plasma levels of prolactin and clinical features were compared between these groups. Results: Negative symptom scores in the group with hyperprolactinemia were significantly higher than in the non-hyperprolactinemic group. There was also a positive correlation between plasma levels of prolactin and negative symptom scores. However, there was no statistically significant difference between schizophrenia subtypes with regard to plasma prolactin levels. Patients treated with conventional neuroleptics or novel antipsychotics such as risperidone, paliperidone and amisulpride had higher prolactin levels than patients treated with aripiprazole, olanzapine, quetiapine, ziprasidone, and clozapine. Conclusion: This study indicated that we should be aware of prolactin levels, especially when negative symptoms are prominent in patients with schizophrenia. Plasma levels of prolactin could be an important biological marker for the severity of negative symptoms in the treatment of patients with schizophrenia. Thus, this finding may change the present pharmacotherapy for negative symptoms in schizophrenia based on prolactin levels.
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Tue, 31 Mar 2015 01:36:33 GMT -08:00 http://www.scopemed.org/?mno=167293
The Role of Atomoxetine and Sympathetic Pathways in Encopresis with ADHD http://www.scopemed.org/?mno=168722 2015-03-31T16-51-00Z
Source: Bulletin of Clinical Psychopharmacology
Atakan Yucel, Nermin Yucel, Elif Oral.
Atomoxetine might affect both ADHD and encopresis via increased noradrenaline levels and sympathetic activity. In our case, we observed the effects of atomoxetine on both encopresis and ADHD; however, this observation needs to be supported with further studies.
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Tue, 31 Mar 2015 01:36:33 GMT -08:00 http://www.scopemed.org/?mno=168722
Evaluation of whole genome association study data in bipolar disorders: potential novel SNPs and genes http://www.scopemed.org/?mno=173817 2015-03-31T16-51-00Z
Source: Bulletin of Clinical Psychopharmacology
Cengizhan Açıkel, Yeşim Aydın Son, Cemil Çelik, Recep Tütüncü.
Objective: As a result of studies of multifactorial conditions, genetic, physiological and environmental factors, the overall heritability of bipolar disorders has been estimated to be up to 70%. In this study, an analysis of genome-wide association study data using data mining algorithms has revealed single-nucleotide polymorphisms that may be the basis for the molecular etiology of bipolar disorders. Methods: The study was conducted as a case-control study, and data from the Whole Genome Association Study of Bipolar Disorder (dbGaP Study Accession: phs000017.v3.p1) were used. The goal of the project was to identify genes that make individuals more susceptible to bipolar disorders. The data set included 1767 controls and 653 bipolar disorder only cases. Genotyping data were generated by Affymetrix Affy 6.0. A total of 934,940 oligos were scanned. Results: Various data mining approaches have identified 6 common SNPs which also have a statistically higher importance than others (rs10415145, rs10857580, rs11023096, rs4654814, rs4792189, rs7569781). rs10415145 is located on chromosome 19 at 19q13.11 and is related to ZNF507 (Zinc Finger Protein 507). While there are no publications reporting ZNF507 in bipolar disorders, a few publications exist studying other zinc finger protein genes. In addition, because it had the highest regulome score, DOCK10 was found to be a potentially related gene. Conclusion: Zinc finger protein genes may play a role in the etiology of bipolar disorders. More detailed studies would help clarify this relation and describe its pathway.
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Tue, 31 Mar 2015 01:36:33 GMT -08:00 http://www.scopemed.org/?mno=173817
Number needed to treat: an important measure for the correct assessment of clinical significance http://www.scopemed.org/?mno=182752 2015-03-31T16-51-00Z
Source: Bulletin of Clinical Psychopharmacology
Mesut Çetin, Selim Kılıç.

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Tue, 31 Mar 2015 01:36:33 GMT -08:00 http://www.scopemed.org/?mno=182752
Carbohydrate-Mediated Drug Targeting-A Review http://www.scopemed.org/?mno=183048 2015-03-31T16-51-00Z
Source: Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery
Kamil Seyrek, Dilek Aksit, Hasan Aksit, Onur Yildiz.
Conventional drugs used in cancer therapy have extended the survival time of patients, however mortality has not significantly decreased. It is evident that there is a need to develop a new, more effective and less toxic compounds in cancer treatment. A promising new approach is based on the deciphering of biological information encoded in β-galactose-containing glycoconjugates and to find out the biological role(s) of carbohydrate binding proteins/galectins, which able to convert encoded information into biological and pathological reactions. Galectins can alter cellular interactions and have important roles in cell cycle, apoptosis and metastases. This review aimed to provide an overview on the potential advantages concerning understanding the mechanism of action of Gal-3 as a therapeutic agent for cancer. Galectin-3 has been found to be upregulated in many types of cancer including colon, gastric, renal and non-small cell lung cancer. Results of several studies indicating that galectin-3 plays a dynamic role in the tumorogenesis and metastatic process, and showing that blockers/inhibitors of galectin-3 could have important therapeutic potential in cancer.
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Mon, 30 Mar 2015 11:25:14 GMT -08:00 http://www.scopemed.org/?mno=183048
Early diagnosis of tendon pathologies with Sonoelastography http://www.scopemed.org/?mno=183610 2015-03-31T16-51-00Z
Source: TAF Preventive Medicine Bulletin
Zeynep İlerisoy Yakut, Törel Oğur, Şükran Erten, Deniz Delibaş, Meltem Yıldırım, Halil Arslan, Mehmet Gümüş.
Aim: Sonoelastography (SE) is a new ultrasound-based imaging technique that provides information on tissue elasticity and stiffness. Strain sonoelastography is the most commonly used technique that allows real-time visualisation of the tissue. In this study, we searched the efficacy of SE for assessing Achilles tendon abnormalities in patients with familial mediterranean fever (FMF) suffering from talalgia.Materials and methods: Achilles tendons of 18 FMF patients suffering from unilateral talalagia with normal X-ray were evaluated by SE. Achilles tendon of symptomatic side is compared with normal (painless) side. Tendons were divided intoproximal, middle, and distal segments. In B-mode examination, tendon thicknesses and echotextures were evaluated. Color-coded images of tendons were obtained by SE. Normal consistent tendon structures were coded as blue or green (type 1). Tendons including yellow areas and red areas were classified as type 2 and type 3 respectively. Moderately (yellow) or severely (red) coded areas were considered pathological.Results: Achilles tendon thicknesses measured at three segments (proximal, middle ,distal). did not show any statistically significant difference in both painless and symptomatic side. Proximal part of achilles tendon’s elasticity did not show any difference in both side (p=0.31). In middle and distal segment , the elasticity was statistically different in symptomatic side than normal side p=0.005 and p=0.001 respectively). Conclusion: Sonoelastographic examination of Achilles tendons in patients with FMF suffering from talalgia may be useful for determining early dejenerative changes in tendons either in the absence of B-mode ultrasound findings.
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Mon, 30 Mar 2015 09:43:49 GMT -08:00 http://www.scopemed.org/?mno=183610
Heat Stress on Poultry Welfare: A Strategic Approach http://www.scopemed.org/?mno=180742 2015-03-31T16-51-00Z
Source: International Journal of Livestock Research
PRADEEPTA KUMAR RATH, Nrusingha Charan Behura, Sarada Prasanna Sahoo, Pratikshya Panda, Kruti Debnath Mandal, Padma Nibash Panigrahi.
In many parts of the world, the poultry industry has conquered a leading position among all the agricultural and allied sectors. Egg and meat industries have shown terrific improvement due to adoption of modernised managemental tools and preventive measures to lethal diseases. On the other hand, heat stress has emerged as one of the major constraint for future development of this industry particularly in the hot and humid parts of the world. Since birds are deprived of sweat glands thermoregulation becomes challenging in hot weather. Affected birds become poor producers and huge death in the flock can also be observed in some cases. Therefore, the sole objective of this review is to gather and deliver available scientific reports on heat stress in poultry including it’s prevention measures.
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Mon, 30 Mar 2015 09:40:35 GMT -08:00 http://www.scopemed.org/?mno=180742
Results of open reduction and internal fixation in closed bimalleolar Pott’s Fracture of Ankle in Adults http://www.scopemed.org/?mno=178224 2015-03-31T16-51-00Z
Source: International Journal of Medical Science and Public Health
Girish N Motwani, Himanshu D Shah, Vishwanath H Chavli, Rajiv N Daveshwar, Haresh Parmar, Pokhraj P Suthar.
Background: The movement around ankle joint is very important because of the cultural practices, which involve squatting and sitting cross-legged. Bimalleolar Pott’s fractures are very common in ankle joint injuries because of increased incidence of road traffic accidents and industrial trauma. Accurate reduction of fractures around ankle joint is important for a painless ankle joint. Objective: To study the functional outcome of surgically managed closed bimalleolar fractures of ankle in adults; to evaluate restoration of the anatomy of malleoli and ankle perfectly by operative treatment with internal fixation; to assess the union of fractures after surgical management; and to achieve stable fixation and early mobilization of the ankle. Materials and Methods: We have evaluated clinical, radiographic, and functional outcomes of 40 patients treated with a combination of different treatment modalities, which involve the combination of tension band wiring (TBW), Kirschner (K)-wire, Rush pin, cortical and cancellous screws, and one-third tubular plates for lateral and medial malleolus fixation. Results: In this prospective study, 40 cases of bimalleolar fractures of ankle were treated by surgical methods. Road traffic accident was the most common mode of injury. Majority [16 (40%)] of the cases showed supination–external rotation injury, followed by 11 (27.5%) cases with pronation–external rotation injury. Majority [29 (72.5%)] of the medial malleolus fractures were fixed with TBW. In the remaining cases, cancellous screws and K-wire were used. Most [20 (50%)] of the lateral malleolar fractures were fixed with K-wire. In the rest of the cases, one-third tubular plate and Rush pin were used. In our study, the average time taken for union was 10.4 weeks. Excellent results were achieved in 23 cases (57.5%), good in 10 cases (25%), fair in five cases (12.5%), and poor in two cases (5%). Excellent results were observed in most bimalleolar fractures. Of the two cases with poor results, one developed superficial infection and the other showed delayed union. Conclusion: Unstable bimalleolar ankle fractures are common because of road traffic accidents. Understanding the mechanism of injury is essential for anatomical reduction and fixation. Fibular alignment (length and rotation) has to be maintained for lateral stability of the ankle. Anatomical reduction with restoration of the articular congruence is essential in all intra-articular fractures, more so, if a weight-bearing joint such as ankle is involved. Open reduction and internal fixation restores the articular congruity of the ankle joint. Excellent results are obtained with stable fixation of fracture. TBW is better in internal fixation of medial malleolus compared with K-wire fixation, and lateral plating was the best for fibular fractures. Hence, we conclude that surgical management of bimalleolar ankle fractures provides good functional outcome. By stable surgical fixation of fracture, early mobilization can be done with good functional outcome.
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Mon, 30 Mar 2015 07:51:55 GMT -08:00 http://www.scopemed.org/?mno=178224
A study on the prevalence of sexually transmitted infections, the health care-seeking behavior, and the barriers for the treatment of sexually transmitted infections in the urban slums of Davangere http://www.scopemed.org/?mno=178145 2015-03-31T16-51-00Z
Source: International Journal of Medical Science and Public Health
Vandana C Khargekar, Sarvamangala Koujalgi.
Background: The control of sexually transmitted infections (STIs) is an urgent health priority because STIs are a major public health problem in all countries, particularly developing countries. STIs can lead to major morbidity and mortality. Since the advent of the HIV/AIDS epidemic, there is good evidence that the control of STIs can reduce HIV transmission. In India, the prevalence of self-reported STIs in the population aged 15–49 years is found to be between 21.9 to 92%. The challenge is to develop new interventions and identify barriers to treatment. Objectives: To know the prevalence of STIs using modified syndromic approach among the slum population, the health care-seeking behaviors and their association with various factors, and the barriers for treatment of STIs. Materials and Methods: Interview method involving a predesigned, pretested, and semistructured questionnaire was used to identify married women with symptoms who were referred for clinical examination. A cross-sectional study design was chosen. Study setting was in four slums of Davangere. Study period was from September 1 to 30, 2013 and the sample size comprised 200 married women in the age group of 18–49 years. Data were described as proportions and categorically analyzed using chi-squared test. Results: About 22% were in the age group of 28–32 year. About 25.5% had STIs out of which only 58.8% took treatment. The main barriers identified were fear, no time, and not caring for symptoms. Conclusion: Slum residents need education to recognize symptoms requiring treatment, and the involvement of partners for treatment should be emphasized upon. The main interventions that could reduce the STIs include IEC campaigns, behavior change communication, and condom promotion.
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Mon, 30 Mar 2015 07:51:20 GMT -08:00 http://www.scopemed.org/?mno=178145