Allergen specific immunotherapy is administered to asthmatic patients and allergic rhinitis treatment. Local and systemic reactions can occur after administration of allergen specific immunotherapy. Our case was a patient with allergic rhinoconjunctivitis whose complaints could not be controlled by medical treatment and eventually subcutaneous immunotherapy was administered. Approximately ten minutes after subcutaneous injection during the initial phase of conventional immunotherapy, the patient developed shortness of breath, cough and pruritus and was diagnosed with anaphylaxis due to immunotherapy. We aim to emphasize that severe systemic reactions (anaphylaxis) can occur due to immunotherapy injections which are effectively used in the treatment of allergic rhinitis and asthma.