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The Effects of Serum Neurotensin-C Levels on Insulin Resistance in Polycystic Ovary Patients

Sureyya Kaplan; Ercan Yilmaz; Ebru Inci Coskun; Baris Ciplak; Pinar Kirici.

Aim: Neurotensin has a role in the onset of diabetes mellitus. In this study, we aim to compare serum neurotensin levels between obese and non-obese patients with PCOS.
Materials and Methods: Patients were divided into four groups. We measured and calculated the following parametres: age, BMI, biochemical and hormonal profiles, and serum neurotensin levels. The results were compared within the groups. As statistical methods, we used the chi-square test and the Mann-Whitney-U test.
Results: We found certain differences between the PCOS patients and control groups. Mean values of age, FGS, and LH levels were higher than those of the control groups. LH levels were higher in the non-obese PCOS patients than the non-obese control group patients. Weight, BMI, LDL, and triglycride levels were also higher in the obese PCOS patients than the non-obese PCOS patients. HOMA-IR values were found to be highest in the obese PCOS patients. There was no significant difference between the groups in terms of NT. Evaluating the results, we observed that NT levels were similar in the non-obese PCOS patients (NT:0,67±0,709) and obese control group patients (NT:0,66±1,47). Similarly, NT levels were quite similar in the obese PCOS patients (NT: 0,43±0,362) and non-obese control patients (NT:0,47±0,406).
Conclusion: It was determined that lipid profile and HOMA-IR values are higher in patients with PCOS. Also, in non-obese PCOS patients and obese control group, the lipid profile, HOMA-IR values, fasting glucose and fasting insulin levels are determined to be significantly higher than the values of the non-obese control group. However, no significant difference was found in NT values between the patient groups.

Key words: Polycystic Over Syndrome;Diabetes Mellitus;Neurotensin-C

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Journal of Interdisciplinary Histopathology


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