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In vitro Screening for Protein Tyrosine Phosphatase 1B and Dipeptidyl Peptidase IV Inhibitors from Nigerian Medicinal Plants

Yusuf Saidu; Suleiman Alhaji Muhammad; Abdullahi Abbas Yahaya; Andrew Onu; Ibrahim Tsado Mohammed; Luba Muhammad.

Abstract
Background/Aim: Protein tyrosine phosphatase 1B (PTP1B) and dipeptidyl peptidase IV (DPP IV) have been identified as one of the drug target for the treatment of type 2 diabetes. The current study was designed to screen for PTP1B and DPP IV inhibitors from some Nigerian medicinal plants.
Methods: PTP 1 B and DPP IV Drug Discovery Kits from Enzo Life Sciences were used to investigate in vitro inhibitory effect of crude methanolic extract of 10 plants; Mangifera indica, Moringa oleifera, Acacia nilotica, Arachis hypogea, Senna nigricans, Azadirachta indica, Calotropis procera, Leptadenia hastata, Ziziphus mauritiana and Solanum incanum.
Results: The result indicated PTP IB inhibition by Senna nigricans (68.2±2.29%), Azadirachta indica (67.4±2.80%), Arachis hypogea (57.2±2.50%), Acacia nilotica (55.1±2.19%) and Moringa oleifera (41.2±1.87%) were significantly (P0.05) different from that of sumarin. The DPP IV inhibition by S. incanum (68.1±2.71%) was significantly higher as compared with a known inhibitor, P32/98. S. nigrican (57.0±1.91%), Z. mauritiana (56.6±2.01%), A. hypogea (51.0±1.30%), M. indica (44.6±2.40%), C procera (36.2±2.00%), A. nilotica (35.4±2.10%) and A. indica (33.6±1.50%) show significantly (P

Key words: Type 2 diabetes;PTP IB;DPP IV;inhibition;medicinal plants



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