Antiepileptic drugs (AEDs) have been used for centuries in the treatment of seizures in both humans and animals. There are different varieties of AEDs to choose from, the choice of an AED is determined by the seizure type, effectiveness of the drug in controlling seizure, cost and the side effects of the drug used. Epilepsy therapy could be monotherapy, that is, the use of an appropriate AED or polytherapy in which case, two AEDs are combined particularly in the case of refractory epilepsy. The side effects of AEDs are diverse and affect virtually all the systems of the body. This review is aimed at studying the side effects associated with the administration of carbamazepine, phenytoin and their combination on learning, memory, locomotion and rearing activities in Wistar rats. Generally, the side effects of AEDs observed are not so detrimental because the discontinuation of the drugs usually cause a reverse of the effects observed. For this review, available informations on the effects of antiepileptic drugs on neurobehavioural activities were accessed from electronic databases.