Bacteria pathogens may cause a serious loss in aquaculture and also health hazards to humans. On the basis of biochemical characteristics and API-20E system, the highest prevailing isolate was identified as Aeromonas sobria. Infection with Aeromonas sobria in African catfish (Clarias gariepinus) induced focal hemorrhage at the end of gill operculum, generalized edema and ulcers on skin surface. Internal signs of infection includes hyperemia of the hepatic artey, coagulative necrosis in the liver and hydropic degeneration of renal tubules according to the histopathological examination. In-vivo the combination of ciprofloxacin and clove extract was the choice as an alternative bacterial therapeutic agents in infected Clarias gariepinus with Aeromonas sobria. Moreover histopathological changes have is the base for the evaluation of fish health.