Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Article

J App Pharm Sci. 2017; 7(2): 016-024


Application of surface plasmon resonance of citrate capped silver nanoparticles for the selective determination of some fluoroquinolone drugs

Sayed M. Derayea; Mahmoud A. Omar; Mohamed A. Hammad; Yasser F. Hassan.

Abstract
Citrate capped silver nanoparticles (Ag NPs) was used as a colorimetric probe for the sensitive determination of six drugs belongs to fluoroquinolone family (Ciprofloxacin, Lomefloxacin, Ofloxacin, Pefloxacin, Levofloxacin and Moxifloxacin). The interaction between the studied fluoroquinolones and citrate-capped Ag NPs resulted in the appearance of new surface plasmon resonance (SPR) peaks measured in the range of 598 – 696 nm. Under the optimized conditions, good linear relationships (R2 = 0.9973–0.9991) were obtained in the range of 1.50–10.25 , 2.0–10.25, 2.0–10.50, 2.0–10.50, 1.5–10.0 and 2.0–11.0 µg/mL for Ciprofloxacin, Ofloxacin, Levofloxacin, Moxifloxacin, Lomefloxacin and Pefloxacin, respectively. The analytical performance of the method was fully validated, and the results were satisfactory. Different pharmaceutical dosage forms containing the cited drugs were successfully analyzed by the suggested method with high degree of accuracy and precision. The proposed method is environmentally safe as it use water as a solvent and does not involve solvent extraction.

Key words: Surface plasmon resonance spectroscopy;Fluoroquinolones;Silver nanoparticles;Pharmaceutical analysis



Share this Article


Advertisement
American Journal of Physiology, Biochemistry and Pharmacology

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
ScopeMed Home
Follow ScopeMed on Twitter
BiblioCAM
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons