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Original Article

J App Pharm Sci. 2017; 7(2): 093-100


Formulation and Evaluation of Chronotherapeutic Pulsatile Drug Delivery System Containing Rabeprazole Sodium

Ashish Kumar Garg; Aakrshan Kumar; Sunita Rani; Mandeep Singh; Amit Sharma; Rajesh Kumar.

Abstract
Pulsatile Drug Delivery systems (PDDS) are basically time-controlled drug delivery systems in which the system controls the lag time and drug is released in an immediate or extended fashion. The present study was conducted to develop and evaluate pulsatile release tablets of Rabeprazole sodium for the treatment of peptic ulcers. The compression coated tablets consisted of a core tablet containing drug with superdisintegrant, which was further coated by erodible outer layer consisted of HPMC K4M, ethyl cellulose and xanthan gum. After carrying out preformulation studies, the developed tablets were evaluated for post-compression parameters like weight variation, thickness, hardness, friability, drug content and in-vitro drug release study. The best formulation was selected on the basis of post-compression parameters and was subjected to accelerated stability studies for 1 month. Amongst 6 formulations prepared, C5 produced convincing results with a maximum cumulative drug release of 99.97% in 195 minutes. Also the formulation didn’t show any significant changes during 1 month period of stress testing. By virtue of its release pattern of delivering the drug at the right time, right place and in right amounts, the developed delivery system holds good promises of benefiting the patients suffering from peptic ulcers.

Key words: Pulsatile;Chronotherapeutic;Circadian rhythms;Proton pump inhibitor;Superdisintegrant



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