Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access

Original Research

IJCRR. 2017; 9(20): 24-29

Histopathological Study of Ocular Surface Squamous Neoplasia in Biopsies Received at Tertiary Care Centre

Neetal Desai; Ami Shah; Hansa Goswami.

Introduction: Ocular surface squamous neoplasia(OSSN) is an encompassing term for pre-cancerous and cancerous epithelial lesions of the conjunctiva and cornea which includes Dysplasia, Carcinoma in-situ (CIS) and Invasive Squamous Cell Carcinoma. OSSN is mostly unilateral, occurs in middle aged to older patients. It is associated with factors such as HIV and xeroderma pigmentosum.
Aims and Objectives:
1) To evaluate incidence of Dysplasia and Squamous Cell Carcinoma in biopsies received
2) To study the spectrum of histopathological findings in Ocular Surface Squamous Neoplasia
Materials and Method: We examined 52 ocular surface biopsies received in our tertiary care centre during the period of 22 months (August-2015 to May-2017). Slides stained with Hematoxylin and Eosin were examined and dysplasia found in biopsies were categorized into mild, moderate and severe. Invasive squamous cell carcinomas were again categorized according to differentiation into well differentiated, moderately differentiated and poorly differentiated. In addition to these 52 biopsies, 10 biopsies were excluded from the study which showed normal or only hyperplastic squamous epithelium.
Results: Out of 52 biopsies examined, 2 cases showed squamous papilloma,13 cases showed dysplasia-mild being the commonest and 37 cases showed invasive carcinoma, moderate differentiation being the commonest.
Conclusion: OSSN is common in middle age and male gender and usually occurs in limbal conjunctiva. Histopathology remains the gold standard for accurate diagnosis and grading of OSSN. Despite increasing awareness, Invasive carcinoma is more prevalent than dysplasia. Prognosis largely depends upon grade and differentiation of tumor and specific microscopic type.

Key words: Dysplasia;Squamous Cell Carcinoma;HIV;Xeroderma Pigmentosum

Share this Article

Applied Medical Research


ScopeMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons