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Original Article

J Islam Int Med Coll. 2017; 12(4): 208-212


Clinical and Histopathological Parameters of the Patients with Breast Cancer from North West Pakistani Population

Asif Ali; Mushtaq Ahmad; Nabila Javeed; Muhammad Ijaz; MahMuneer Khan; Rauf Khattak; Mazhar Khan; Afsheen Hasnain Daud; Asma Fayyaz; Muhammad Naseem Khan; Abdul Salam; Zoufishan Rahat; Maham Israr; Muhammad Suhaib Qudus; Rabia Zahir; Waqas Khan; Zia Ul-Haq.

Abstract
Objective: To analyze the clinical and histopathologic parameters of patients with breast cancer from the north
West population of Pakistan.
Study Design: Cross sectional descriptive study.
Place and Duration of Study: Data was extracted from the Institute of Radiology and Nuclear Medicine
Hospital, Peshawar and Khyber Teaching Hospital, Peshawar from March 2014 to December 2016.
Materials and Methods: Demographic, clinical and histopathological data was extracted from patient files
using proformas. The following parameters were assessed: age, family history, marital status, side and type of
surgery, resection margins, tumor markers, foci, tumor grade, TNM stage and lymph node, vascular and
lymphatic invasion. Data was analyzed for descriptive statistics. Logistic regression was performed by
stratifying patients according to the disease stage as early stage (ES) (stage I and II) and late stage (LS) (stage III
and IV) to get odds ratios (ORs) and P -values.
Results: Clinical and histopathological data of 362 patients with breast cancer was profiled. From the available
data 82 (33%) patients were early stage breast cancer, while 167 (67%) were late stage breast cancer. The mean
age of patients in the ES breast cancer (45.8 years) was not statistically different from LS breast cancer (45.8
years) (p=0.99).
ER+ cases were 62%, PR+ cases were 47% and HER2 positive cases were 49%. Lymph node invasion (p

Key words: Breast Cancer;Clinico-pathologic;Estrogen Receptors;HER2-Neu Peptide;Lymph Nodes;Progesterone Receptor



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