Objective: To determine the frequency of Subclinical hypothyroidism in patients with chronic kidney disease.
Study Design: Cross sectional study.
th th Place and Duration of Study: Department of Medicine Military Hospital Rawalpindi, from 20 July 2015 to 05
Materials and Methods: In this study 250 patients were included, 50 patients for each stage of chronic kidney
disease (CKD) starting from stage II to stage V and 50 peoples were from normal control group. Serum
Creatinine, Thyroid Stimulating hormone (TSH) and Free T4 (thyroxine) were measured. Data was analyzed by
SPSS version 17. The quantitative variables like age, free T4 and TSH was presented in mean and standard
deviation for each group. Qualitative variables such as sex and presence or absence of subclinical
hypothyroidism was reported as frequencies percentages for each group. Comparison of TSH level in four
stages of CKD and control group was performed by using Kruskal Wallis ANOVA. Mann Whitening U test was
used for Post Hoc analysis if required. Comparison of frequency of Subclinical hypothyroidism among groups
was performed by using Chi-Square likelihood ratio. P value lower than 0.05 was taken statistically significant.
Results: Frequency of Subclinical hypothyroidism was 04 % in normal control group. Frequency of Subclinical
hypothyroidism was 06%,10%,12% and 16% in stage II, III, IV and V respectively. Frequency of Subclinical
hypothyroidism was increases with decrease of GFR. Frequency of Subclinical hypothyroidism was slightly
increased preponderance in female as compared to male.
Conclusion: Frequency of subclinical hypothyroidism is higher in CKD patients than normal population, but it is
statistically not significant.
Chronic Kidney Disease;Hypothyroidism;Subclinical Hypothyroidism;Subclinical Primary