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Effect of Amoxicillin on Haematobiochemical Parameters in Poultry

Madhuchhanda Khan; Uttam Sarkar; Tapan Kumar Mandal.

Amoxicillin is one of the amino-penicillin β-lactam antibiotics widely used in poultry medicine because of its broad spectrum of antimicrobial activity, good absorption and penetration into tissues. The present study was carried out to explore the effect of Amoxicillin on haematobiochemical parameters in poultry. Amoxicillin was administered orally to layer hen (Rhode Island Red) at therapeutic (20 mg kg-1) and subtherapeutic (10 mg kg-1 )dose level for consecutive 14 days and the activities of some antioxidant enzymes and malondialdehyde (MDA) blood levels were studied. Amoxicillin produced a nonsignificant increase of haemoglobin , total leucocyte count and heterophil count in layer hens of different groups at different days compared to control group following daily oral administration for consecutive 14 days. Values of blood glucose level and serum protein level of amoxicillin treated group of birds decreased nonsignificantly compared to control birds. On the other hand, Amoxicillin caused a nonsignificant decrease of lymphocyte and eosinophil count in layer hens of different groups at different days compared to control group. Plasma ALT, AST and serum lipid peroxidation activity in treated groups of layer poultry were increased significantly (P

Key words: Amoxicillin;Antioxidant enzyme;Haematobiochemical parameter;Antioxidant enzyme;Malondialdehyde

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Journal of Molecular Pathophysiology


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