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Salivary cortisol level as a marker of adrenal function in children with systemic inflammatory response syndrome in Egypt.

adel hamed elbaih; Amany elkilany; Maha enany.

Abstract
Introduction: Pediatric systemic inflammatory response syndrome (SIRS) criteria is widely used to identify patients who need specialized, advanced therapies. Cortisol plays an important anti-inflammatory in SIRS. Adrenal status and use of corticosteroid in children with SIRS still controversial.

Objective: to assess salivary in children with SIRS and its relation to outcome in PICU of Suez Canal University hospital.

Methods: prospective case control study was carried out. We analyzed 45 patients with SIRS and45 healthy control children for morning salivary and total serum cortisol level

Results: children with SIRS have significantly higher morning salivary and total serum cortisol level than control group (p=.00). Mortality was associated with higher levels of both salivary and total cortisol.

Conclusions: Salivary cortisol can be used to estimate cortisol levels in pediatric with SIRS and can foretell outcome.

Keywords: systemic inflammatory response syndrome, children, salivary, cortisol.

Key words:   Keywords: systemic inflammatory response syndrome;children;salivary;cortisol



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