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. 2018; 3(2): 85-91

Effects of Saint John’s wort on the fetus in pregnant rats

Basak Buyuk; Mehmet Yuncu; Ayhan Eralp; Serap Inaloz Demir.

Introduction: Because of the toxic and teratologic side effects that might develop
into the fetus, the number of drugs that can be used in the treatment of
depression seen in pregnancy is very limited. In this study, we investigated
whether the Saint John’s wort used during pregnancy has side effects on the
liver of fetus.Methods: Thirteen Wistar albino female rats were used in this study. The animals
divided into two groups as 8 rats for the experimental group and 5 rats for the
control group.  The animals detected for
pregnancy in the experimental group were fed with the Saint John’s wort extract
as 100 mg/kg/day through orogastric probe from the first day of the pregnancy.
The animals in the control group were fed with 2 ml distiled water through an
orogastric probe every day begining from the first day of the pregnancy. The
newborn pups were taken. Their liver tissues were harvested and investigated after
the tissue processing and staining procedure.Results: Microvesicular lipidosis and hydropic degeneration were observed in
histopathological evaluation of the harvested tissues of experimental group.

Conclusion: As a result, there is not enough data in the literature in order to
claim that Saint John’s worth is reliable for the pregnant women or fetus. It
is important for the physician to evaluate the complaints related to the use of
pregnancy and to raise the awareness of the physicians in the first stage of
the pregnancy follow-up. For the usage of this herb as an alternative or
addition to antidepressive drugs more preclinical (basic) and clinical studies
need to be performed.

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American Journal of Physiology, Biochemistry and Pharmacology


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