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Journal Article

. 2018; 3(3): 123-126


Relationship of serum netrin-1 levels with breast masses

Ibrahim Solak; Duygu Ilke Yildirim; Mustafa Solak; Cigdem Damla Cetinkaya; Ayse Boyaci; Mehmet Ali Eryilmaz.

Abstract
Introduction: Netrin-1
has been shown to induce angiogenesis and is considered to function as a
proto-oncogene. We aimed to evaluate the relationship of serum netrin-1 level
with the presence of breast mass and the nature of mass.Methods: A total of
84 patients, including 27 patients with benign mass, 31 patients with malignant
mass and 26 healthy controls, were enrolled in the study. Results: In our
study, the mean serum netrin-1 level was 479±325 pg/ml in the patients with
malignant mass, 336.9±178.2 pg/ml in the patients with benign mass and
264.7±112.4 pg/ml in the healthy controls, respectively. There was a
statistically significant difference in mean serum netrin-1 level between these
three groups (p=0.007). When the patients participating in the study were
divided in to two groups as those with (the benign and malign groups) and
without (the control group) mass, the mean serum netrin-1 level was 264.7±112.4
pg/ml in those without mass and 412.8±274.2 pg/ml in those with mass,
respectively. It was seen that the mean serum netrin-1 level of those with mass
was statistically significantly higher than that of those without mass
(p=0.016).





Conclusion: The mean
serum netrin-1 level was found to be significantly higher in the patients with
breast mass, especially those with malignant mass.



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