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Adverse drug reactions report among hospitalized patients with hypertension in a Nigerian Tertiary Healthcare Centre: a retrospective study

Abiola Muhammad Adeosun; Aduragbenro D.A. Adedapo; Waheed Adeola Adedeji.

Abstract
Adverse drug reactions (ADRs) are serious clinical problem with growing global concern. This study focused on incidence and outcome of ADRs among in-patients with hypertension in Nigeria. This is a descriptive, cross-sectional study on incidence of adverse drug reactions among in-patients with hypertension conducted in the University College Hospital (UCH), Ibadan, Nigeria, within June 2012 to May 2013. Of 196 patients, 105 (53.6%) were male, and 91 (46.4%) were female. Prevalence of ADRs was 53 (27.04%), of these, 28 (52.8%) were male, and 25 (47.2%) were female patients. Adverse drug reaction was cause of admission in 2 (1.02%) patients. Prevalence of ADRs during hospitalized was 51 (26.02%) patients. Patients with adverse drug event spent approximately additional 5 days more in bed compared to those without adverse drug reactions (p = 0.028) . ADRs experienced by the patients were managed by withdrawing the suspected drug(s). ADR recorded among hospitalised patients with hypertension was 27.04%. ADR was cause of admission in 1% of in-patients with hypertension. Patients that experienced ADR spent additional five days in hospital compared to those without adverse drug effect during hospitalization.

Key words: Adverse drug reaction;hospitalized patients;incidence;hypertension;dechallenge



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