Neuromyelitis optica spectrum disorder(NMOSD) is an autoimmune demyelinating disorder of the central nervous system that predominantly affects the optic nerves and the spinal cord. Magnetic resonance imaging (MRI) has increasingly important role in differentiating NMOSD from other inflammatory disorders of the central nervous system, particularly multiple sclerosis (MS). Specific antibodies against aquaporin-4(AQP4) were identified and found to be directly responsible for the pathogenesis of the disease. We report on an AQP4 antibody-positive 12-year-old female with radiological findings in her brain MRI.
Aquaporin-4;neuromyelitis optica spectrum disorder;pediatric