Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access

Original Article

Synthesis, Pharmacological Evaluation, Molecular Docking and in silico ADMET Prediction of Nitric Oxide Releasing Biphenyls as Anti-Inflammatory Agents

Monika G. Shinde; Siddharth J. Modi; Vithal M. Kulkarni.

Various substituted 2-(4'-methyl-N-phenyl-[1,1'-biphenyl]-2-ylcarboxamido)-2-oxoethyl nitrate derivatives were synthesized and evaluated for analgesic, anti-inflammatory and ulcerogenic activity and for their ability to release nitric oxide. Compounds VM 4, VM 6, VM 9, VM 10 and VM 12 exhibited good analgesic and anti-inflammatory activity compared to standard drug diclofenac. The compounds also showed decreased gastro-intestinal ulcerogenicity and gastro-protective activity in histopathological studies resulting in absence of mucosal injury. All the synthesized compounds were found to have significant in vivo nitric oxide releasing activity. The molecular docking was performed to understand the binding mode of these compounds. Results of this study indicated that these NO-NSAIDs may have affinity towards COX-2 active site which can further be explored for selective or non-selective inhibitors.

Key words: Biphenyl derivatives;Synthesis;Docking;ADMET;Anti-inflammatory activity

Share this Article

Journal of Molecular Pathophysiology


ScopeMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons